Over-representation of specific regions of chromosome 22 in cells from human glioma correlate with resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea

Table 1 Patient information

Tumor code^a	Age^b	Sex	Diagnosis^c	Treatment^d	Days between primary and secondary surgery	Survival (days)
DI/DIR	38	F	GBM	Irradiation and BCNU	111	426
LX/LXR	48	M	Gliosarc./GBM^e	Irradiation and BCNU	203	466
ME/MER	49	F	GBM	Irradiation and BCNU	138	285

^a The tumor code is a random 2 letter code. Recurrent tumor from the same patient receives the same code with the addition of R. For each patient the primary and recurrent tumors were diagnosed by the same neuropathologist.
^b Age in years at diagnosis of primary tumor.
^c GBM = glioblastoma multiforme; gliosarc. = gliosarcoma.
^d BCNU = 1,3-bis(2-chloroethyl)-1-nitrosourea.
^e Different diagnoses of primary and recurrent tumors. Gliosarcoma is considered a variant of glioblastoma multiforme and the gliomatous and sarcomatous areas have similar genetic profiles and are thought to have a monoclonal origin [22,23]. Tumor LX was primarily glial, with a small sarcomatous element.

ISSN: 1471-2407