Tumour Severity | Subgroups | Genotype frequencies (%) | Chi square test for trend (P value) | ||
---|---|---|---|---|---|
 |  | 1:1 | 1:2 | 2:2 |  |
IL1A +4845 G>T | |||||
Tumour Grade | Grade 1 (n = 122) | 62 (50.8%) | 50 (41%) | 10 (8.2%) | X2 = 0.037; p = 0.85 |
 | Grade 2 (n = 283) | 151 (53.4%) | 109 (38.5%) | 23 (8.1%) |  |
 | Grade 3 (n = 216) | 115 (53.2%) | 82 (38%) | 19 (8.8%) |  |
Nodal Involvement | Absent (n = 430) | 204 (47.4%) | 118 (43.7%) | 38 (8.8%) | X2 = 4.75; p = 0.03* |
 | Present (n = 117) | 117 (59.4%) | 63 (32%) | 17 (8.6%) |  |
Vascular Invasion | Absent (n = 467) | 243 (52%) | 185 (39.6%) | 39 (8.4%) | X2 = 0.058; p = 0.81 |
 | Present (n = 117) | 64 (54.7%) | 42 (35.9%) | 11 (9.4%) |  |
IL1B -511 C>T | |||||
Tumour Grade | Grade 1 (n = 126) | 51 (40.5%) | 59 (46.8%) | 16 (12.7%) | X2 = 0.12; p = 0.73 |
 | Grade 2 (n = 284) | 150 (52.8%) | 111 (39.1%) | 23 (8.1%) |  |
 | Grade 3 (n = 216) | 98 (45.4%) | 93 (43.1%) | 25 (11.6%) |  |
Nodal Involvement | Absent (n = 434) | 214 (49.3%) | 179 (41.2%) | 41 (9.4%) | X2 = 0.79; p = 0.37 |
 | Present (n = 198) | 90 (45.5%) | 87 (43.9%) | 21 (10.6%) |  |
Vascular Invasion | Absent (n = 473) | 224 (47.4%) | 201 (42.5%) | 48 (10.1%) | X2 = 0.38; p = 0.54 |
 | Present (n = 116) | 57 (49.1%) | 50 (43.1%) | 9 (7.8%) |  |
IL1B +3954 C>T | |||||
Tumour Grade | Grade 1 (n = 121) | 68 (56.2%) | 48 (39.7%) | 5 (4.1%) | X2 = 0.053; p = 0.82 |
 | Grade 2 (n = 279) | 173 (62%) | 90 (32.3%) | 16 (5.7%) |  |
 | Grade 3 (n = 215) | 131 (60.9%) | 70 (32.6%) | 14 (6.5%) |  |
Nodal Involvement | Absent (n = 427) | 244 (57.1%) | 161 (37.7%) | 22 (5.2%) | X2 = 0.37; p = 0.54 |
 | Present (n = 194) | 120 (61.9%) | 61 (31.4%) | 13 (6.7%) |  |
Vascular Invasion | Absent (n = 464) | 283 (61%) | 157 (33.8%) | 24 (5.2%) | X2 = 0.43; p = 0.51 |
 | Present (n = 114) | 66 (57.9%) | 41 (36%) | 7 (6.1%) |  |
IL1RN +2018 T>C | |||||
Tumour Grade | Grade 1 (n = 125) | 55 (44%) | 55 (44%) | 15 (12%) | X2 = 0.73; p = 0.40 |
 | Grade 2 (n = 280) | 150 (53.6%) | 107 (38.2%) | 23 (8.2%) |  |
 | Grade 3 (n = 215) | 108 (50.2%) | 86 (40%) | 21 (9.8%) |  |
Nodal Involvement | Absent (n = 429) | 216 (50.3%) | 180 (42%) | 33 (7.7%) | X2 = 0.11; p = 0.74 |
 | Present (n = 196) | 102 (52%) | 72 (36.7%) | 22 (11.2%) |  |
Vascular Invasion | Absent (n = 463) | 232 (50.1%) | 191 (41.3%) | 40 (8.6%) | X2 = 1.34; p = 0.25 |
 | Present (n = 118) | 67 (56.8%) | 42 (35.6%) | 9 (7.6%) |  |
IL4R +1902 A>G | |||||
Tumour Grade | Grade 1 (n = 137) | 87 (63.5%) | 44 (32.1%) | 6 (4.4%) | X2 = 0.14; p = 0.71 |
 | Grade 2 (n = 308) | 195 (63.3%) | 97 (31.5%) | 16 (5.2%) |  |
 | Grade 3 (n = 228) | 146 (64%) | 75 (32.9%) | 7 (3.1%) |  |
Nodal Involvement | Absent (n = 477) | 313 (65.6%) | 144 (30.2%) | 20 (4.2%) | X2 = 0.11; p = 0.75 |
 | Present (n = 212) | 135 (63.7%) | 69 (32.5%) | 8 (3.8%) |  |
Vascular Invasion | Absent (n = 508) | 316 (62.2%) | 170 (33.5%) | 22 (4.3%) | X2 = 0.002; p = 0.96 |
 | Present (n = 129) | 82 (63.6%) | 40 (31%) | 7 (5.4%) |  |
IL6 -174 G>C | |||||
Tumour Grade | Grade 1 (n = 80) | 26 (32.5%) | 38 (47.5%) | 16 (20%) | X2 = 0.04; p = 0.84 |
 | Grade 2 (n = 204) | 78 (38.2%) | 95 (46.6%) | 31 (15.2%) |  |
 | Grade 3 (n = 159) | 49 (30.8%) | 83 (52.2%) | 27 (17%) |  |
Nodal Involvement | Absent (n = 293) | 100 (34.1%) | 141 (48.1%) | 52 (17.7%) | X2 = 0.20; p = 0.66 |
 | Present (n = 143) | 52 (36.4%) | 67 (46.9%) | 24 (16.8%) |  |
Vascular Invasion | Absent (n = 325) | 112 (34.5%) | 159 (48.9%) | 54 (16.6%) | X2 = 0.001; p = 0.98 |
 | Present (n = 85) | 29 (34.1%) | 42 (49.4%) | 14 (16.5%) |  |
IL10 -1082 G>A | |||||
Tumour Grade | Grade 1 (n = 80) | 23 (28.8%) | 37 (46.3%) | 20 (25%) | X2 = 0.37; p = 0.54 |
 | Grade 2 (n = 205) | 39 (19%) | 113 (55.1%) | 53 (25.9%) |  |
 | Grade 3 (n = 158) | 44 (27.8%) | 79 (50%) | 35 (22.2%) |  |
Nodal Involvement | Absent (n = 293) | 69 (23.5%) | 148 (50.5%) | 76 (25.9%) | X2 = 0.84; p = 0.36 |
 | Present (n = 143) | 38 (26.6%) | 73 (51%) | 32 (22.4%) |  |
Vascular Invasion | Absent (n = 325) | 87 (26.8%) | 156 (48%) | 82 (25.2%) | X2 = 3.3; p = 0.07 |
 | Present (n = 85) | 12 (14.1%) | 49 (57.6%) | 24 (28.2%) |  |