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Table 5 Genotype frequencies of the seven polymorphisms in subgroups of breast cancer and control populations

From: Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review

Subsets Case/control Genotype Frequencies (%) Chi square test for trend (p value)
   1:1 1:2 2:2  
IL1A +4845 G>T
Overall Cancers (n = 697) 360 (51.6%) 275 (39.5%) 62 (8.9%) X2 = 3.71; p = 0.05
  Controls (n = 498) 215 (43.2%) 245 (49.2%) 38 (7.6%)  
Positive Family History Cancers (n = 192) 106 (55.2%) 71 (37%) 15 (7.8%) X2 = 2.74; p = 0.10
  Controls (n = 104) 44 (42.3%) 52 (50%) 8 (7.7%)  
Negative Family History Cancers (n = 505) 254 (50.3%) 204 (40.4%) 47 (9.3%) X2 = 1.47; p = 0.23
  Controls (n = 394) 171 (43.4%) 193 (49%) 30 (7.6%)  
Young cancers vs. controls Cancers (n = 113) 55 (48.7%) 43 (38%) 15 (13.3%) X2 = 0; p = 0.98
  Controls (n = 498) 215 (43.2%) 245 (49.2%) 38 (7.6%)  
IL1B -511 C>T
Overall Cancers (n = 703) 339 (48.2%) 294 (41.8%) 70 (10%) X2 = 0.10; p = 0.75
  Controls (n = 489) 232 (47.4%) 206 (42.1%) 51 (10.4%)  
Positive Family History Cancers (n = 195) 96 (49.2%) 85 (43.6%) 14 (7.2%) X2 = 0.45; p = 0.51
  Controls (n = 103) 48 (46.6%) 45 (43.7%) 10 (9.7%)  
Negative Family History Cancers (n = 508) 243 (47.8%) 209 (41.1%) 56 (11%) X2 = 0.003; p = 0.96
  Controls (n = 386) 184 (47.7%) 161 (41.7%) 41 (10.6%)  
Young cancers vs. controls Cancers (n = 115) 55 (47.8%) 49 (42.6%) 11 (9.6%) X2 = 0.033; p = 0.86
  Controls (n = 489) 232 (47.4%) 206 (42.1%) 51 (10.4%)  
IL1B +3954 C>T
Overall Cancers (n = 691) 410 (59.3%) 242 (35%) 39 (5.6%) X2 = 1.12; p = 0.29
  Controls (n = 420) 231 (55%) 167 (39.8%) 22 (5.2%)  
Positive Family History Cancers (n = 193) 129 (66.8%) 55 (28.5%) 9 (4.7%) X2 = 8.75; p = 0.003*
  Controls (n = 91) 43 (47.3%) 41 (45.1%) 7 (7.7%)  
Negative Family History Cancers (n = 498) 281 (56.4%) 187 (37.6%) 30 (6%) X2 = 0.26; p = 0.61
  Controls (n = 329) 188 (57.1%) 126 (38.3%) 15 (4.6%)  
Young cancers vs. controls Cancers (n = 112) 64 (57.1%) 41 (36.6%) 7 (6.3%) X2 = 0.03; p = 0.86
  Controls (n = 420) 231 (55%) 167 (39.8%) 22 (5.2%)  
IL1RN +2018 T>C
Overall Cancers (n = 697) 349 (50.1%) 286 (41%) 62 (8.9%) X2 = 0.05; p = 0.82
  Controls (n = 490) 247 (50.4%) 202 (41.2%) 41 (8.4%)  
Positive Family History Cancers (n = 193) 94 (48.7%) 84 (43.5%) 15 (7.8%) X2 = 0.074; p = 0.79
  Controls (n = 103) 48 (46.6%) 47 (45.6%) 8 (7.8%)  
Negative Family History Cancers (n = 504) 255 (50.6%) 202 (40.1%) 47 (9.3%) X2 = 0.14; p = 0.71
  Controls (n = 387) 199 (51.4%) 155 (40.1%) 33 (8.5%)  
Young cancers vs. controls Cancers (n = 113) 61 (54%) 44 (38.9%) 8 (7.1%) X2 = 0.53; p = 0.47
  Controls (n = 490) 247 (50.4%) 202 (41.2%) 41 (8.4%)  
IL4R +1902 A>G
Overall Cancers (n = 775) 493 (63.6%) 249 (32.1%) 33 (4.3%) X2 = 2.1; p = 0.15
  Controls (n = 767) 451 (58.8%) 288 (37.5%) 28 (3.7%)  
Positive Family History Cancers (n = 212) 133 (62.7%) 70 (33%) 9 (4.2%) X2 = 0.19; p = 0.66
  Controls (n = 168) 98 (58.3%) 66 (39.3%) 4 (2.4%)  
Negative Family History Cancers (n = 563) 360 (63.9%) 179 (31.8%) 24 (4.3%) X2 = 2.00; p = 0.16
  Controls (n = 599) 353 (58.9%) 222 (37.1%) 24 (4.0%)  
Young cancers vs. controls Cancers (n = 122) 85 (69.7%) 36 (29.5%) 1 (0.8%) X2 = 6.36; p = 0.012*
  Controls (n = 767) 451 (58.8%) 288 (37.5%) 28 (3.7%)  
IL6 -174 G>C
Overall Cancers (n = 497) 170 (34.2%) 244 (49.1%) 83 (16.7%) X2 = 0.05; p = 0.83
  Controls (n = 490) 168 (34.3%) 235 (48%) 87 (17.8%)  
Positive Family History Cancers (n = 127) 47 (37%) 55 (43.3%) 25(19.7%) X2 = 0.20; p = 0.66
  Controls (n = 102) 38 (37.3%) 48 (47.1%) 16(15.7%)  
Negative Family History Cancers (n = 370) 123 (33.2%) 189 (51.1%) 58 (15.7%) X2 = 1.22; p = 0.64
  Controls (n = 388) 130 (33.5%) 187 (48.2%) 71 (18.3%)  
Young cancers vs. controls Cancers (n = 85) 36 (42.4%) 31 (36.5%) 18 (21.2%) X2 = 0.31; p = 0.58
  Controls (n = 490) 168 (34.3%) 235 (48%) 87 (17.8%)  
IL10 -1082 G>A
Overall Cancers (n = 497) 121 (24.3%) 253 (50.9%) 123 (24.7%) X2 = 0.01; p = 0.93
  Controls (n = 498) 117 (23.5%) 260 (52.2%) 121 (24.3%)  
Positive Family History Cancers (n = 126) 31 (24.6%) 69 (54.8%) 26 (20.6%) X2 = 0.39; p = 0.54
  Controls (n = 104) 31 (29.8%) 52 (50%) 21 (20.2%)  
Negative Family History Cancers (n = 371) 90 (24.3%) 184 (49.6%) 97 (26.1%) X2 = 0.11; p = 0.74
  Controls (n = 394) 86 (21.8%) 208 (52.8%) 100 (25.4%)  
Young cancers vs. controls Cancers (n = 84) 17 (20.2%) 44 (52.4%) 23 (27.4%) X2 = 0.60; p = 0.44
  Controls (n = 498) 117 (23.5%) 260 (52.2%) 121 (24.3%)  
  1. Note: Family history: either first or second degree relative with breast cancer. Young cancer patients: </=50 years of age