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Table 10 Studies of the IL6 -174G>C polymorphism in breast cancer.
| Reference | Numbers studied | Type of controls | Susceptibility | Severity | Ethnicity | |
|---|---|---|---|---|---|---|
| Cancer | Controls | |||||
| Smith KC et al, 2004 [57] | 144 | 224 | Bone marrow and solid organ donors – male and female | No association | No association | mixed |
| Hefler LA et al, 2005 [58] | 269 | 227 | Women visiting outpatient dept for various reasons | OR = 1.5 (1.04–2.3)* for GC vs. GG OR = 2 (1.1–3.6)* for CC vs. GG | No association | Caucasian |
| Skerrett DL et al, 2005 [59] | 88 | 102 | Maternal cord blood samples | No association | No association | mixed |
| Saha A et al, 2003 [60] | 26 | 95 | Unknown | No association | Not studied | Asian Indian |
| DeMichelle A et al, 2003 [61] | 80 | 0 | - | Not studied | C allele associated with 4 year disease free survival (p = 0.02) and overall survival (p = 0.01) in node positive patients | mixed |
| Iacopetta B et al, 2004 [62] | 256 | 0 | - | Not studied | C allele associated with high grade (p = 0.04) and CC genotype associated with poor survival (p = 0.03) | mixed |
| Our study | 497 | 490 | Women with normal mammograms from screening population | No association | No association | British Caucasian |
