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Table 10 Studies of the IL6 -174G>C polymorphism in breast cancer.

From: Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review

Reference Numbers studied Type of controls Susceptibility Severity Ethnicity
  Cancer Controls     
Smith KC et al, 2004 [57] 144 224 Bone marrow and solid organ donors – male and female No association No association mixed
Hefler LA et al, 2005 [58] 269 227 Women visiting outpatient dept for various reasons OR = 1.5 (1.04–2.3)* for GC vs. GG OR = 2 (1.1–3.6)* for CC vs. GG No association Caucasian
Skerrett DL et al, 2005 [59] 88 102 Maternal cord blood samples No association No association mixed
Saha A et al, 2003 [60] 26 95 Unknown No association Not studied Asian Indian
DeMichelle A et al, 2003 [61] 80 0 - Not studied C allele associated with 4 year disease free survival (p = 0.02) and overall survival (p = 0.01) in node positive patients mixed
Iacopetta B et al, 2004 [62] 256 0 - Not studied C allele associated with high grade (p = 0.04) and CC genotype associated with poor survival (p = 0.03) mixed
Our study 497 490 Women with normal mammograms from screening population No association No association British Caucasian
  1. OR: Odds Ratio