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Table 6 Relationships between methylation alterations and clinicopathological variables in gastric cancers (n = 39) containing high-level and low-level chromosomal losses

From: The 5'-end transitional CpGs between the CpG islands and retroelements are hypomethylated in association with loss of heterozygosity in gastric cancers

  

Mean frequency of methylation alterations* (%, mean ± SD)

Clinicopathological variables

No. of patients

Hypomethylation

p†

Hypermethylation

p†

Age (years)

     

   ≤55

7

34.7 ± 28.4

0.547

11.2 ± 9.1

0.384

   >55

32

29.0 ± 20.1

 

16.5 ± 15.2

 

Tumor size (cm)

     

   ≤5

24

24.7 ± 16.7

0.056

17.3 ± 15.6

0.359

   > 5

15

38.6 ± 27.4

 

12.9 ± 12.1

 

Sex

     

   Male

27

28.8 ± 22.2

0.619

14.5 ± 15.0

0.514

   Female

12

32.7 ± 22.9

 

17.8 ± 13.1

 

Lauren classification

     

   Intestinal

26

28.0 ± 21.3

0.727

18.1 ± 15.0

0.189

   Diffuse

8

34.8 ± 29.4

 

13.4 ± 12.9

 

   Mixed

5

32.9 ± 15.6

 

5.7 ± 9.3

 

Differentiation

     

   Well

3

23.8 ± 10.9

0.671

23.8 ± 8.2

0.169

   Moderate

24

28.6 ± 22.2

 

17.6 ± 15.3

 

   Poor

12

34.5 ± 24.7

 

9.5 ± 11.9

 

Growth pattern

     

   Infiltrative

23

32.6 ± 25.6

0.639

13.4 ± 12.9

0.221

   Expanding

3

21.4 ± 14.3

 

28.6 ± 14.3

 

   Mixed

13

27.4 ± 16.7

 

16.5 ± 16.1

 

Venous invasion

     

   Yes

4

37.5 ± 16.9

0.485

1.8 ± 3.6

0.041

   No

35

29.2 ± 22.7

 

17.1 ± 14.3

 

Lymphatic invasion

     

   Yes

21

38.8 ± 25.2

0.006

9.5 ± 10.4

0.003

   No

18

19.8 ± 12.1

 

22.6 ± 15.3

 

Tumor stage

     

   Early stage

23

23.0 ± 15.1

0.015

19.9 ± 15.7

0.023

   Advanced stage

16

40.2 ± 26.9

 

9.4 ± 9.7

 
  1. *Methylation alterations were detected in 14 transitional CpG amplicons.
  2. †p values were calculated by an independent t test.