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Table 6 Relationships between methylation alterations and clinicopathological variables in gastric cancers (n = 39) containing high-level and low-level chromosomal losses

From: The 5'-end transitional CpGs between the CpG islands and retroelements are hypomethylated in association with loss of heterozygosity in gastric cancers

   Mean frequency of methylation alterations* (%, mean ± SD)
Clinicopathological variables No. of patients Hypomethylation p† Hypermethylation p†
Age (years)      
   ≤55 7 34.7 ± 28.4 0.547 11.2 ± 9.1 0.384
   >55 32 29.0 ± 20.1   16.5 ± 15.2  
Tumor size (cm)      
   ≤5 24 24.7 ± 16.7 0.056 17.3 ± 15.6 0.359
   > 5 15 38.6 ± 27.4   12.9 ± 12.1  
Sex      
   Male 27 28.8 ± 22.2 0.619 14.5 ± 15.0 0.514
   Female 12 32.7 ± 22.9   17.8 ± 13.1  
Lauren classification      
   Intestinal 26 28.0 ± 21.3 0.727 18.1 ± 15.0 0.189
   Diffuse 8 34.8 ± 29.4   13.4 ± 12.9  
   Mixed 5 32.9 ± 15.6   5.7 ± 9.3  
Differentiation      
   Well 3 23.8 ± 10.9 0.671 23.8 ± 8.2 0.169
   Moderate 24 28.6 ± 22.2   17.6 ± 15.3  
   Poor 12 34.5 ± 24.7   9.5 ± 11.9  
Growth pattern      
   Infiltrative 23 32.6 ± 25.6 0.639 13.4 ± 12.9 0.221
   Expanding 3 21.4 ± 14.3   28.6 ± 14.3  
   Mixed 13 27.4 ± 16.7   16.5 ± 16.1  
Venous invasion      
   Yes 4 37.5 ± 16.9 0.485 1.8 ± 3.6 0.041
   No 35 29.2 ± 22.7   17.1 ± 14.3  
Lymphatic invasion      
   Yes 21 38.8 ± 25.2 0.006 9.5 ± 10.4 0.003
   No 18 19.8 ± 12.1   22.6 ± 15.3  
Tumor stage      
   Early stage 23 23.0 ± 15.1 0.015 19.9 ± 15.7 0.023
   Advanced stage 16 40.2 ± 26.9   9.4 ± 9.7  
  1. *Methylation alterations were detected in 14 transitional CpG amplicons.
  2. †p values were calculated by an independent t test.