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Table 2 Matriptase and HAI-1 mRNA levels in normal and affected tissues. The mRNA levels were normalised to β-actin mRNA levels.

From: The ratio of Matriptase/HAI-1mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals

Variable

mRNA level in normal tissue Mean (SD)

Pa

mRNA level in adenomas/carcinomas Mean (SD)

Pa

Pb

Matriptase

     

   Healthy people

0.93 (0.18)

    

   Mild/moderate

1.02 (0.23)

NS

0.86 (0.31)

NS

NS

   Severe

0.74 (0.22)

NS

0.66 (0.24)

NS

NS

   Carcinoma

0.66 (0.36)

NS

0.49 (0.25)

<0.01

NS

   All adenomas and carcinomas

0.85 (0.29)

ND

0.72 (0.31)

ND

<0.01

HAI-1

     

   Healthy people

12.84 (3.70)

    

   Mild/moderate

16.35 (5.22)

NS

7.35 (3.67)

<0.001

<0.001

   Severe

7.55 (2.12)

<0.05

4.93 (1.83)

<0.001

<0.01

   Carcinoma

7.17 (4.79)

<0.05

4.26 (2.25)

<0.001

NS

   All adenomas and carcinomas

11.47 (6.23)

ND

5.89 (3.14)

ND

<0.001

Matriptase/HAI-1 ratio

     

   Healthy people

0.076 (0.018)

    

   Mild/moderate

0.067 (0.024)

NS

0.132 (0.044)

<0.05

<0.001

   Severe

0.102 0.027)

NS

0.142 (0.044)

<0.05

<0.001

   Carcinoma

0.095 (0.036)

NS

0.144 (0.084)

<0.05

NS

   All adenomas and carcinomas

0.085 (0.032)

ND

0.138 (0.053)

ND

<0.001

  1. NS = not significant, ND = not determined
  2. a) p value for the comparison to the expression levels in healthy persons using a one-way ANOVA and Tukey's post test for paired comparisons.
  3. b) p value for the comparison of the expression levels in normal and affected tissue from the same person using a paired T-test