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Table 2 Matriptase and HAI-1 mRNA levels in normal and affected tissues. The mRNA levels were normalised to β-actin mRNA levels.

From: The ratio of Matriptase/HAI-1mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals

Variable mRNA level in normal tissue Mean (SD) Pa mRNA level in adenomas/carcinomas Mean (SD) Pa Pb
Matriptase      
   Healthy people 0.93 (0.18)     
   Mild/moderate 1.02 (0.23) NS 0.86 (0.31) NS NS
   Severe 0.74 (0.22) NS 0.66 (0.24) NS NS
   Carcinoma 0.66 (0.36) NS 0.49 (0.25) <0.01 NS
   All adenomas and carcinomas 0.85 (0.29) ND 0.72 (0.31) ND <0.01
HAI-1      
   Healthy people 12.84 (3.70)     
   Mild/moderate 16.35 (5.22) NS 7.35 (3.67) <0.001 <0.001
   Severe 7.55 (2.12) <0.05 4.93 (1.83) <0.001 <0.01
   Carcinoma 7.17 (4.79) <0.05 4.26 (2.25) <0.001 NS
   All adenomas and carcinomas 11.47 (6.23) ND 5.89 (3.14) ND <0.001
Matriptase/HAI-1 ratio      
   Healthy people 0.076 (0.018)     
   Mild/moderate 0.067 (0.024) NS 0.132 (0.044) <0.05 <0.001
   Severe 0.102 0.027) NS 0.142 (0.044) <0.05 <0.001
   Carcinoma 0.095 (0.036) NS 0.144 (0.084) <0.05 NS
   All adenomas and carcinomas 0.085 (0.032) ND 0.138 (0.053) ND <0.001
  1. NS = not significant, ND = not determined
  2. a) p value for the comparison to the expression levels in healthy persons using a one-way ANOVA and Tukey's post test for paired comparisons.
  3. b) p value for the comparison of the expression levels in normal and affected tissue from the same person using a paired T-test