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Table 4 Associations between estrogen receptor-alpha (ESR1) polymorphisms and breast cancer risk in the BBD cohort

From: Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease

   Cancer No Cancer   
  dbSNP rs# (n = 91) (n = 1347) All Participants Post-menopausal Only
   n % n % Age- Adjusted OR (95% CI) Age-Adjusted OR (95% CI)
ESR1 Pro325Pro 1801132       
   CC   52 57.1 794 58.9 1.00 1.00
   CG   31 34.1 440 32.7 1.07 (0.67, 1.69) 1.06 (0.61, 1.87)
   GG   7 7.7 64 4.8 1.65 (0.72, 3.78) 2.03 (0.81, 5.10)
   CG/GG   38 41.8 504 37.4 1.14 (0.74, 1.76) 1.19 (0.70, 2.01)
   Missing   1 1.1 49 3.6   
ESR1 Ser10Ser 2077647       
   TT   26 28.6 335 24.9 1.00 1.00
   TC   36 39.6 642 47.7 0.71 (0.42, 1.20) 0.90 (0.46, 1.77)
   CC   27 29.7 304 22.6 1.14 (0.65, 1.99) 1.88 (0.94, 3.75)
   TC/CC   63 69.2 946 68.8 0.85 (0.53, 1.37) 1.21 (0.65, 2.24)
   Missing   2 2.2 66 4.8   
ESR1 Ala87Ala 746432       
   GG   67 73.6 1077 80.0 1.00 1.00
   GC   15 16.5 181 13.4 1.32 (0.74, 2.36) 1.24 (0.61, 2.51)
   CC   1 1.1 7 0.5 2.30 (0.28, 18.95) 3.34 (0.38, 29.18)
p-for-trend       0.3 0.3
   GC/CC   16 17.6 188 14.0 1.36 (0.77, 2.39) 1.31 (0.66, 2.60)
   Missing   8 8.8 82 6.1   
ESR1 IVS6+52 2273206       
   GG   69 75.8 1060 78.7 1.00 1.00
   GT   13 14.3 229 17.0 0.86 (0.48, 1.59) 0.71 (0.33, 1.53)
   TT   3 3.3 10 0.7 4.79 (1.29, 17.88) 5.31 (1.04, 27.28)
   GT/TT   16 17.6 239 17.7 1.02 (0.58, 1.79) 0.86 (0.43, 1.73)
   Missing   6 6.6 48 3.6   
ESR1 Thr594Thr 2228480       
   AA   2 2.2 41 3.0 1.00 1.00
   AG   20 22.0 358 26.6 1.14 (0.26, 5.05) 0.88 (0.19, 4.04)
   GG   58 63.7 841 62.4 1.42 (0.34, 6.01) 0.86 (0.20, 3.77)
   AG/GG   78 85.7 1199 89.0 1.34 (0.32, 5.62) 0.87 (0.20, 3.75)
   Missing   11 12.1 107 7.9   
ESR1 – 104062C>T 851982       
   CC   38 41.8 470 34.9 1.00 1.00
   CT   33 36.3 612 45.4 0.65 (0.40, 1.05) 0.55 (0.30, 0.99)
   TT   14 15.4 190 14.1 0.88 (0.47, 1.67) 0.89 (0.43, 1.85)
   CT/TT   47 51.6 802 59.5 0.70 (0.45, 1.09) 0.63 (0.37, 1.08)
   Missing   6 6.6 75 5.6