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Table 4 Association between XRCC1 condon 194 and 399 polymorphisms and NPC risk stratified by smoking status

From: Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population

Genotype Non smoking Smoking
  Cases Controls Adjusted ORa (95%CI) P value Cases Controls Adjusted ORa (95%CI) P value
XRCC1 Arg194Trp
   Arg/Arg 78 157 1.00   154 78 1.00  
   Arg/Trp 58 155 0.73(0.48–1.11) 0.14 108 62 0.87(0.57–1.33) 0.52
   Trp/Trp 10 29 0.77(0.35–1.70) 0.52 9 14 0.34(0.14–0.82) 0.017*
XRCC1 Arg399Gln
   Arg/Arg 85 185 1.00   156 85 1.00  
   Arg/Gln 50 140 0.73(0.47–1.12) 0.14 102 60 0.90(0.59–1.38) 0.62
   Gln/Gln 11 18 1.42(0.63–3.23) 0.40 21 12 0.91(0.41–1.99) 0.81
  1. aAdjusted OR were calculated with the XRCC1 194Arg/Arg or 399Arg/Arg genotype as the reference group and adjusted for age, sex.
  2. * P-value remained significant after Bonferroni's correction.