Gene

Actual occurrence of gene (in 220 rules)

Binomial probability

pvalue (onesided)


KDR

159

9.69E130

<0.00001

MAP2K6

146

1.13E110

<0.00001

ICAM1

121

4.10E78

<0.00001

ANXA5

60

7.04E20

<0.00001

CDK8

56

3.38E17

<0.00001

CDKN1A

55

1.49E16

<0.00001

JUNB

49

6.56E13

<0.00001

TGFBR2

41

1.08E08

<0.00001

TNF

24

1.11E02

0.01490

TNFAIP1

23

1.76E02

0.02599

CCND3

19

6.73E02

0.16020

PDGFRL

18

8.23E02

0.22749

MAPK12

15

1.04E01

0.49264

GAPDH

15

1.04E01

0.49264

PTGS2

12

7.05E02

0.20295

PDGFB

11

5.26E02

0.13246

 Number of genes per rule = 5 (approximately)

$\begin{array}{c}\text{Randomoccurrenceofgene}=\text{Numberofrules}\times \frac{\text{Numberofgenesperrule}}{\text{Totalnumberofgenes}}\\ =220\times \frac{5}{70}=15.71\end{array}$
 Arranged in decreasing order of their frequencies of occurrence in 220 rules, the genes show a general trend towards increasing probability of being selected in a rule by random chance. The postulated frequency of occurrence of each gene if all have equal probabilities of being selected is 15.71. PTGS2 and PDGFB have smaller probabilities than the two genes preceding them because they were actually used less frequently than random chance would suggest.