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Table 4 Probability of gene usage from the set of 70 genes due to random chance.

From: The use of genetic programming in the analysis of quantitative gene expression profiles for identification of nodal status in bladder cancer

Gene Actual occurrence of gene (in 220 rules) Binomial probability p-value (one-sided)
KDR 159 9.69E-130 <0.00001
MAP2K6 146 1.13E-110 <0.00001
ICAM1 121 4.10E-78 <0.00001
ANXA5 60 7.04E-20 <0.00001
CDK8 56 3.38E-17 <0.00001
CDKN1A 55 1.49E-16 <0.00001
JUNB 49 6.56E-13 <0.00001
TGFBR2 41 1.08E-08 <0.00001
TNF 24 1.11E-02 0.01490
TNFAIP1 23 1.76E-02 0.02599
CCND3 19 6.73E-02 0.16020
PDGFRL 18 8.23E-02 0.22749
MAPK12 15 1.04E-01 0.49264
GAPDH 15 1.04E-01 0.49264
PTGS2 12 7.05E-02 0.20295
PDGFB 11 5.26E-02 0.13246
  1. Number of genes per rule = 5 (approximately)
  2. Random occurrence of gene = Number of rules × Number of genes per rule Total number of genes = 220 × 5 70 = 15.71 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=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@AAAE@
  3. Arranged in decreasing order of their frequencies of occurrence in 220 rules, the genes show a general trend towards increasing probability of being selected in a rule by random chance. The postulated frequency of occurrence of each gene if all have equal probabilities of being selected is 15.71. PTGS2 and PDGFB have smaller probabilities than the two genes preceding them because they were actually used less frequently than random chance would suggest.