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Figure 7 | BMC Cancer

Figure 7

From: Molecular profiling of signalling proteins for effects induced by the anti-cancer compound GSAO with 400 antibodies

Figure 7

Effects of GSAO treatment on HUVEC. HUVEC wereincubated for 24 h with GSAO or GSCA as indicated with 15% FBS. A Increased tyrosine phosphorylation is readily detectable at 15 μM GSAO treatment. Some GSAO affected proteins are indicated witharrows. B Hyperphosphorylation of the 100 kDa protein is undetectable in HUVEC, while a band of ca. 120 kDa, the size expected for PRK1/PKNα, remains unchanged. A band shift of Hic-5 is detectable at 50 μM GSAO treatment. Phosphorylation changes in Erk2 at Thr202/Tyr204 are not detectable.

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