Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study

BMC Cancer

Table 4 Reproductive history and related endogenous exposures

Exposure*	Cases n	Controls n	OR (95% CI)†
Age at menarche
< 12	22	44	Referent
12 – 14	100	212	0.9 (0.5 – 1.7)
> 14	21	30	1.2 (0.6 – 2.7)
Number of live births
None	18	58	Referent
1	22	28	2.0 (0.9 – 4.6)
≥ 2	103	200	1.4 (0.7 – 2.6)
Age at first birth
< 20	25	44	Referent
20 – 29	86	159	1.2 (0.6 – 2.4)
≥ 30	14	25	1.2 (0.4 – 3.8)
Ever Breast Feeding
No	57	75	Referent
Yes	71	154	0.7 (0.4 – 1.0)
Menstrual status on reference date**
Menstruating	21	72	Referent
Post-menopausal and not using HRT	38	58	2.8 (1.1 – 7.1)
Menstrual status 10 years before reference date**
Menstruating	35	83	Referent
Post-menopausal and not using HRT	23	46	0.6 (0.2 – 1.9)

* Reported exposure before reference date, which for a case and her two matched controls was the date the case had surgery for her meningioma.
† Odds ratio (OR) and 95% confidence intervals (CI) estimated from multivariable conditional logistic regression including continuous age and three categories of education (high school or less, some college or trade school, and college graduate or graduate school) as confounding variables. None of the tests for linear trend was significant.
** Odds ratio (OR) and 95% confidence intervals (CI) estimated from multivariable unconditional logistic regression including continuous age and three categories of education (high school or less, some college or trade school, and college graduate or graduate school) as confounding variables.

ISSN: 1471-2407