Figure 5
Anti-tumor effects of tPA and D-penicillamine in a human melanoma xenograft model. Nude mice xenografted with human melanoma BLM were treated with tPA, D-penicillamine, or a combination of tPA and D-penicillamine. Shown are mean tumor volumes of at least 5 mice/treatment modality plus/minus SD. A reduction in tumor growth of 58% was observed by applying the combination treatment schedule. Treatment schedules: 
: none; 
: D-penicillamine; 
: tPA; 
: tPA and D-penicillamine