|
Nucleosomal DNA fragments (ng/mL)
|
|
Effect of therapy response on nucleosomal DNA
|
0.017
|
|
Effect of time after start of chemotherapy (days) on nucleosomal DNA
|
0.023
|
|
Interaction between therapy response and time
|
0.495
|
|
Day 1 (before therapy)
|
15
|
65.2
|
22.3 – 267.1
|
7
|
30.3
|
16.0 – 90.9
|
0.104
|
|
Day 2
|
18
|
86.4
|
21.7 – 807.7
|
6
|
25.7
|
17.7 – 128.1
|
0.014
|
|
Day 3
|
18
|
63.5
|
11.4 – 657.8
|
6
|
21.2
|
12.0 – 50.3
|
0.051
|
|
Day 4
|
16
|
44.6
|
9.7 – 613.8
|
5
|
14.9
|
12.0 – 36.0
|
0.022
|
|
Day 5
|
16
|
36.0
|
12.6 – 154.4
|
6
|
31.5
|
12.0 – 86.4
|
0.530
|
|
Day 6/7/8
|
18
|
24.0
|
9.2 – 2031.2
|
6
|
16.6
|
9.2 – 38.3
|
0.060
|
|
Day 2 – Day 1 %
|
15
|
2.5
|
-76 – 305
|
6
|
-16.5
|
-35.3 – 40.9
|
0.259
|
|
Thymidine kinase (U/L)
|
|
Effect of therapy response on thymidine kinase
|
0.750
|
|
Effect of time after start of chemotherapy (days) on thymidine kinase
|
0.001
|
|
Interaction between therapy response and time
|
0.360
|
|
Day 1 (before therapy)
|
15
|
50.6
|
6 – 603
|
7
|
40.9
|
10 – 1095
| |
|
Day 2
|
17
|
88.9
|
1 – 727
|
6
|
54.1
|
22 – 127
| |
|
Day 3
|
18
|
183.0
|
5 – 1789
|
6
|
121.2
|
47 – 998
| |
|
Day 4
|
15
|
302.0
|
25 – 1158
|
5
|
85.6
|
58 – 772
| |
|
Day 5
|
14
|
194.5
|
22 – 1161
|
6
|
193.5
|
57 – 758
| |
|
Day 6/7/8
|
18
|
175.5
|
29 – 1040
|
7
|
146.0
|
36 – 414
| |
|
Day 2 – Day 1 %
|
14
|
21.9
|
-90 – 626
|
6
|
50.2
|
-63 – 110
|
0.970
|
|
Lactate dehydrogenase (U/L)
|
|
Effect of therapy response on LDH
|
0.251
|
|
Effect of time after start of chemotherapy (days) on LDH
|
0.161
|
|
Interaction between therapy response and time
|
0.359
|
|
Day 1 (before therapy)
|
10
|
346
|
120 – 672
|
5
|
326
|
202 – 427
| |
|
Day 2
|
10
|
373
|
177 – 1603
|
4
|
237
|
147 – 391
| |
|
Day 3
|
11
|
361
|
204 – 876
|
3
|
278
|
183 – 282
| |
|
Day 4
|
9
|
533
|
153 – 1068
|
3
|
285
|
217 – 330
| |
|
Day 5
|
9
|
380
|
182 – 1405
|
3
|
318
|
218 – 440
| |
|
Day 6/7/8
|
12
|
304
|
174 – 1087
|
4
|
261
|
232 – 336
| |
|
Leukocytes (G/L)
|
|
Effect of therapy response on leukocytes
|
0.193
|
|
Effect of time after start of chemotherapy (days) on leukocytes
|
<0.001
|
|
Interaction between therapy response and time
|
0.914
|
|
Day 1 (before therapy)
|
14
|
3.4
|
1.2 – 52.5
|
7
|
3.4
|
0.7 – 37.4
| |
|
Day 2
|
16
|
3.7
|
0.5 – 43.1
|
6
|
2.2
|
0.6 – 30.3
| |
|
Day 3
|
16
|
3.8
|
0.5 – 23.0
|
5
|
1.6
|
0.9 – 17.0
| |
|
Day 4
|
13
|
2.1
|
0.6 – 22.3
|
3
|
1.7
|
0.9 – 5.4
| |
|
Day 5
|
11
|
1.7
|
0.7 – 3.4
|
3
|
0.8
|
0.7 – 1.5
| |
|
Day 6/7/8
|
13
|
0.9
|
0.5 – 21.6
|
3
|
0.9
|
0.5 – 1.1
| |
|
Day 2 – Day 1 %
|
13
|
-1.4
|
-61 – 79
|
6
|
-35.4
|
-54 – -14.3
|
0.059
|
|
Bone Marrow Blast Number (%)
|
|
Day 1 (before therapy)
|
18
|
72
|
7 – 90
|
7
|
74
|
25 – 93
|
0.880
|
|
Day 16
|
17
|
0
|
0 – 6
|
6
|
4
|
0 – 72
|
0.385
|
|
Day 1 – Day 16 %
|
17
|
100
|
14 – 100
|
6
|
88
|
3 – 100
|
0.385
|
