Table 2 Correlation of nucleosomal DNA, thymidine kinase, lactate dehydrogenase, leukocytes and bone marrow blast number with response to therapy
| Â | Complete response | No response | P-value | ||||
|---|---|---|---|---|---|---|---|
| Â | N | Median | Range | N | Median | Range | Â |
Nucleosomal DNA fragments (ng/mL) | |||||||
Effect of therapy response on nucleosomal DNA | 0.017 | ||||||
Effect of time after start of chemotherapy (days) on nucleosomal DNA | 0.023 | ||||||
Interaction between therapy response and time | 0.495 | ||||||
Day 1 (before therapy) | 15 | 65.2 | 22.3 – 267.1 | 7 | 30.3 | 16.0 – 90.9 | 0.104 |
Day 2 | 18 | 86.4 | 21.7 – 807.7 | 6 | 25.7 | 17.7 – 128.1 | 0.014 |
Day 3 | 18 | 63.5 | 11.4 – 657.8 | 6 | 21.2 | 12.0 – 50.3 | 0.051 |
Day 4 | 16 | 44.6 | 9.7 – 613.8 | 5 | 14.9 | 12.0 – 36.0 | 0.022 |
Day 5 | 16 | 36.0 | 12.6 – 154.4 | 6 | 31.5 | 12.0 – 86.4 | 0.530 |
Day 6/7/8 | 18 | 24.0 | 9.2 – 2031.2 | 6 | 16.6 | 9.2 – 38.3 | 0.060 |
Day 2 – Day 1 % | 15 | 2.5 | -76 – 305 | 6 | -16.5 | -35.3 – 40.9 | 0.259 |
Thymidine kinase (U/L) | |||||||
Effect of therapy response on thymidine kinase | 0.750 | ||||||
Effect of time after start of chemotherapy (days) on thymidine kinase | 0.001 | ||||||
Interaction between therapy response and time | 0.360 | ||||||
Day 1 (before therapy) | 15 | 50.6 | 6 – 603 | 7 | 40.9 | 10 – 1095 |  |
Day 2 | 17 | 88.9 | 1 – 727 | 6 | 54.1 | 22 – 127 |  |
Day 3 | 18 | 183.0 | 5 – 1789 | 6 | 121.2 | 47 – 998 |  |
Day 4 | 15 | 302.0 | 25 – 1158 | 5 | 85.6 | 58 – 772 |  |
Day 5 | 14 | 194.5 | 22 – 1161 | 6 | 193.5 | 57 – 758 |  |
Day 6/7/8 | 18 | 175.5 | 29 – 1040 | 7 | 146.0 | 36 – 414 |  |
Day 2 – Day 1 % | 14 | 21.9 | -90 – 626 | 6 | 50.2 | -63 – 110 | 0.970 |
Lactate dehydrogenase (U/L) | |||||||
Effect of therapy response on LDH | 0.251 | ||||||
Effect of time after start of chemotherapy (days) on LDH | 0.161 | ||||||
Interaction between therapy response and time | 0.359 | ||||||
Day 1 (before therapy) | 10 | 346 | 120 – 672 | 5 | 326 | 202 – 427 |  |
Day 2 | 10 | 373 | 177 – 1603 | 4 | 237 | 147 – 391 |  |
Day 3 | 11 | 361 | 204 – 876 | 3 | 278 | 183 – 282 |  |
Day 4 | 9 | 533 | 153 – 1068 | 3 | 285 | 217 – 330 |  |
Day 5 | 9 | 380 | 182 – 1405 | 3 | 318 | 218 – 440 |  |
Day 6/7/8 | 12 | 304 | 174 – 1087 | 4 | 261 | 232 – 336 |  |
Leukocytes (G/L) | |||||||
Effect of therapy response on leukocytes | 0.193 | ||||||
Effect of time after start of chemotherapy (days) on leukocytes | <0.001 | ||||||
Interaction between therapy response and time | 0.914 | ||||||
Day 1 (before therapy) | 14 | 3.4 | 1.2 – 52.5 | 7 | 3.4 | 0.7 – 37.4 |  |
Day 2 | 16 | 3.7 | 0.5 – 43.1 | 6 | 2.2 | 0.6 – 30.3 |  |
Day 3 | 16 | 3.8 | 0.5 – 23.0 | 5 | 1.6 | 0.9 – 17.0 |  |
Day 4 | 13 | 2.1 | 0.6 – 22.3 | 3 | 1.7 | 0.9 – 5.4 |  |
Day 5 | 11 | 1.7 | 0.7 – 3.4 | 3 | 0.8 | 0.7 – 1.5 |  |
Day 6/7/8 | 13 | 0.9 | 0.5 – 21.6 | 3 | 0.9 | 0.5 – 1.1 |  |
Day 2 – Day 1 % | 13 | -1.4 | -61 – 79 | 6 | -35.4 | -54 – -14.3 | 0.059 |
Bone Marrow Blast Number (%) | |||||||
Day 1 (before therapy) | 18 | 72 | 7 – 90 | 7 | 74 | 25 – 93 | 0.880 |
Day 16 | 17 | 0 | 0 – 6 | 6 | 4 | 0 – 72 | 0.385 |
Day 1 – Day 16 % | 17 | 100 | 14 – 100 | 6 | 88 | 3 – 100 | 0.385 |