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Table 2 Correlation of nucleosomal DNA, thymidine kinase, lactate dehydrogenase, leukocytes and bone marrow blast number with response to therapy

From: Early prediction of therapy response in patients with acute myeloid leukemia by nucleosomal DNA fragments

  Complete response No response P-value
  N Median Range N Median Range  
Nucleosomal DNA fragments (ng/mL)
Effect of therapy response on nucleosomal DNA 0.017
Effect of time after start of chemotherapy (days) on nucleosomal DNA 0.023
Interaction between therapy response and time 0.495
Day 1 (before therapy) 15 65.2 22.3 – 267.1 7 30.3 16.0 – 90.9 0.104
Day 2 18 86.4 21.7 – 807.7 6 25.7 17.7 – 128.1 0.014
Day 3 18 63.5 11.4 – 657.8 6 21.2 12.0 – 50.3 0.051
Day 4 16 44.6 9.7 – 613.8 5 14.9 12.0 – 36.0 0.022
Day 5 16 36.0 12.6 – 154.4 6 31.5 12.0 – 86.4 0.530
Day 6/7/8 18 24.0 9.2 – 2031.2 6 16.6 9.2 – 38.3 0.060
Day 2 – Day 1 % 15 2.5 -76 – 305 6 -16.5 -35.3 – 40.9 0.259
Thymidine kinase (U/L)
Effect of therapy response on thymidine kinase 0.750
Effect of time after start of chemotherapy (days) on thymidine kinase 0.001
Interaction between therapy response and time 0.360
Day 1 (before therapy) 15 50.6 6 – 603 7 40.9 10 – 1095  
Day 2 17 88.9 1 – 727 6 54.1 22 – 127  
Day 3 18 183.0 5 – 1789 6 121.2 47 – 998  
Day 4 15 302.0 25 – 1158 5 85.6 58 – 772  
Day 5 14 194.5 22 – 1161 6 193.5 57 – 758  
Day 6/7/8 18 175.5 29 – 1040 7 146.0 36 – 414  
Day 2 – Day 1 % 14 21.9 -90 – 626 6 50.2 -63 – 110 0.970
Lactate dehydrogenase (U/L)
Effect of therapy response on LDH 0.251
Effect of time after start of chemotherapy (days) on LDH 0.161
Interaction between therapy response and time 0.359
Day 1 (before therapy) 10 346 120 – 672 5 326 202 – 427  
Day 2 10 373 177 – 1603 4 237 147 – 391  
Day 3 11 361 204 – 876 3 278 183 – 282  
Day 4 9 533 153 – 1068 3 285 217 – 330  
Day 5 9 380 182 – 1405 3 318 218 – 440  
Day 6/7/8 12 304 174 – 1087 4 261 232 – 336  
Leukocytes (G/L)
Effect of therapy response on leukocytes 0.193
Effect of time after start of chemotherapy (days) on leukocytes <0.001
Interaction between therapy response and time 0.914
Day 1 (before therapy) 14 3.4 1.2 – 52.5 7 3.4 0.7 – 37.4  
Day 2 16 3.7 0.5 – 43.1 6 2.2 0.6 – 30.3  
Day 3 16 3.8 0.5 – 23.0 5 1.6 0.9 – 17.0  
Day 4 13 2.1 0.6 – 22.3 3 1.7 0.9 – 5.4  
Day 5 11 1.7 0.7 – 3.4 3 0.8 0.7 – 1.5  
Day 6/7/8 13 0.9 0.5 – 21.6 3 0.9 0.5 – 1.1  
Day 2 – Day 1 % 13 -1.4 -61 – 79 6 -35.4 -54 – -14.3 0.059
Bone Marrow Blast Number (%)
Day 1 (before therapy) 18 72 7 – 90 7 74 25 – 93 0.880
Day 16 17 0 0 – 6 6 4 0 – 72 0.385
Day 1 – Day 16 % 17 100 14 – 100 6 88 3 – 100 0.385