The area under the curve of nucleosomal DNA values of days 2–4 of induction therapy (AUC 2–4) discriminates between patients with complete remission and those with no remission. A) AUC 2–4 of nucleosomal DNA is significantly larger for patients with complete response (CR ■) than for those not responsive (no CR ●) to therapy (p = 0.042). Here, median levels of days 1 to 4 and the respective AUC 2–4 are shown for both response groups. B) Distribution of AUC 2–4 levels of nucleosomal DNA. Favourable therapy response can be predicted with a sensitivity of 56% and a specificity of 100% at a cutoff level of 150 ng/mL*d.