Skip to main content

Table 3 Stratified analysis on association between the TS3'-UTR del6 polymorphism and risk of breast cancer

From: Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis

Variables n (cases/controls) TS3'-UTR del6
   n (cases/controls)    aAdjusted OR (95% CI)   
   del6/del6 del6/ins6 ins6/ins6 del6/del6 del6/ins6 ins6/ins6
Age
≤ 48 158/195 80/98 69/76 9/21 1.00 1.11(0.70–1.76) 0.65(0.27–1.56)
> 48 274/278 114/118 139/125 21/35 1.00 1.08(0.74–1.58) 0.53(0.28–1.00)
Menopausal status
Premenopausal 197/210 93/105 90/82 14/23 1.00 1.22(0.80–1.86) 0.75(0.36–1.56)
Postmenopausal 235/263 101/111 118/119 16/33 1.00 1.01(0.68–1.50) 0.45(0.22–0.90)
Age at menarche
<16 239/152 103/70 117/69 19/13 1.00 1.06(0.68–1.64) 0.87(0.39–1.91)
≥16 193/321 91/146 91/132 11/43 1.00 1.13(0.77–1.65) 0.39(0.19–0.81)
bAge at first live birth
≤ 25 166/226 70/91 85/104 11/31 1.00 1.04(0.67–1.61) 0.47(0.22–1.03)
>25 253/234 116/118 120/95 17/21 1.00 1.24(0.82–1.87) 0.95(0.45–2.03)
Family history of cancer
No 319/378 143/173 155/165 21/40 1.00 1.07(0.77–1.48) 0.63(0.35–1.13)
Yes 113/95 51/43 53/36 9/16 1.00 1.27(0.69–2.35) 0.45(0.17–1.21)
  1. aAdjusted for the other covariates presented in this table in a logistic regression model for each stratum.
  2. b Age at first live birth information was available in 460 controls and 419 breast cancer cases.