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Table 1 Comparison of breast cancer cases and controls by selective characteristics

From: Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis

Variable Controlsc (n = 473) Breast cancer (n = 432) P value
Age, yr (mean ± SD) 51.42 ± 11.12 52.09 ± 11.03 0.36
Age at menarche, yr (mean ± SD) 16.40 ± 1.77 15.32 ± 1.92 <0.0001
Age at first live birth, yr (mean ± SD) a 24.49 ± 2.47 25.51 ± 3.45 <0.0001
Age at menopausal, yr (mean ± SD) b 49.79 ± 3.88 48.89 ± 4.26 0.02
BMI 23.69 ± 3.35 23.95 ± 3.55 0.25
Menopausal status    0.74
   Premenopausal 210(44.4) 197(45.6)  
   Postmenopausal 263(55.6) 235(54.4)  
Family History of Cancer    0.033
Positive 95(20.1) 113(26.2)  
Negative 378(79.9) 319(73.8)  
TSER    0.987
3R allele 753(79.6) 688(79.8)  
2R allele 193(20.4) 176(20.2)  
TS 3'-UTR del6    0.347
del6 allele 633(66.9) 596(69.0)  
ins6 allele 313(33.1) 268(31.0)  
Haplotypes of TSER and TS 3'-UTR del6 polymorphisms    0.863
3R-del6 295(62.4) 271(62.6)  
3R-ins6 83(17.5) 73(17.0)  
2R-del6 25(5.3) 28(6.4)  
2R-ins6 70(14.8) 60(14.0)  
  1. a Age at first live birth information was available in 460 controls and 419 breast cancer cases.
  2. b Age at menopausal information was available in 226 controls and 227 breast cancer cases with postmenopausal status.
  3. cThree controls carrying the rare alleles of more than three 28 bp repeats (>3R) were excluded in the current analyses.