Table 3 One-way sensitivity analysis.
Variables | Base- Case Values | Sensitivity Analysis Values | Incremental Cost($)/Life-Year Saved | |||||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | DNA3 | DNA5 | DNA10 | |||
| Â | Â | Â | Range | Threshold | Range | Threshold | Range | Threshold |
Base-case | Â | Â | 9,794 | Â | 9,335 | Â | 7,717 | Â |
Sensitivity of DNA for small/large adenoma | 8%/15% | 75%/82% | 11,546 – 1,742 | -- | 11,122 – 1,030 | -- | 9,369 – 269 | -- |
Sensitivity of DNA for preclinical CRC | 52% | 50%–100% | 9,921 – 7,078 | -- | 9,454 – 6,752 | -- | 7,817 – 5,528 | -- |
Cost per DNA | $44.1 | $22.1-$88.1 | 4,344 – 2,0706 | $57.1 | 4,194 – 19,628 | $60.0 | 3,271 – 1,6618 | $70.3 |
Compliance with DNA | 60% | 10%–100% | 9,070 – 10,423 | -- | 9,047 – 9,582 | -- | 7,630 – 7,787 | -- |
Referral rate to diagnostic colonoscopy | 85% | 10%–100% | 85,266 – 8,294 | 67% | 83,868 – 7,843 | 63% | 73,826 – 6,396 | 53% |
Prevalence of large adenoma | 3.82% | 0.96%–7.64% | 18,969 – 5,387 | 2.42% | 18,184 – 5,114 | 2.23% | 15,657 – 4,042 | 1.58% |
Discount rate | 3% | 0%–7% | 6,938 – 15,674 | -- | 6,738 – 14,864 | -- | 5,107 – 13,281 | -- |