Table 1 Somatic VHL gene deletion and mutation in MEN 2A-associated medullary thyroid carcinomas/CCH with germline mutations of RET
From: Somatic VHLgene alterations in MEN2-associated medullary thyroid carcinoma
Case | RETgermline Mutation | LOH at the VHLlocus | Somatic VHLMutation | Allelic imbalance of RET |
|---|---|---|---|---|
1 | Codon 620 TGC/CGC | Yes | del C nt 389 Exon 1 | Yes (D10S677) |
2 | Codon 618 TGC/AGC | Yes | No | Yes (D10S677) |
3 | Codon 609 TGC/CGC | Yes | N/A | Yes (D10S677) |
4 | Codon 609 TGC/CGC | No | N/A | No |
5 | Codon 609 TGC/CGC | No | No | No |
6 | Codon 609 TGC/CGC | No | No | No |
7 (CCH) | Codon 634 TGC/CGC | No | No | No |