Table 2 Literature review – patient characteristics, treatment and outcomes – abbreviations and reference list
Name (Country) | Year | n | Pathology (number of cases) | Successful non-operative biopsy | Resection | Chemotherapy | Radiotherapy | Outcome without resection, chemotherapy or RT | Outcomes with resection | Outcomes with chemotherapy without resection or RT | Outcomes with chemotherapy and RT without resection |
|---|---|---|---|---|---|---|---|---|---|---|---|
Hart USA | 1987 | 14 | Histiocytcic (9) Poorly diff lymphocytic (2) Well diff lymphocytic (1) T cell (1) Undifferentiated (1) | 0 of 14 | 1 of 14 | CHOP (14) | 1 of 14 | 0 | 1 NR (Received CHOP, RT NR) | 6 alive at mean 32 months (18–48 months) 2 died within 3 months 5 died at mean 35 months (6–108) (5 of 13 received RT) | |
Webb USA | 1989 | 2** | DLBCL (6) Follicular mixed (2) Small cleaved (1) | 1 of 2 | MACOP-B (1) | 0 of 2 | 0 | 1 alive at 95 months (Received CAMEL, 0 RT) | 1 alive at 21 months | 0 | |
Mansour England | 1989 | 12 | NR | 0 of 12 | 1 of 12 | CHOP (9) | 5 of 12 | 2 died in post-op period after bypass | 1 NR (Received chemo, RT NR) | 4 alive at 3,36,48,84 months 5 died at 2–11 months (5 of 9 received RT) | |
Tuchek USA | 1993 | 7 | NR | 0 of 7 | 0 of 7 | CHOP (1) CVP (1) CAMEL (1) | 0 of 7 | 4 died – mean survival 5 months | 0 | 3 alive at 60,72,96 months | 0 |
Behrns USA | 1994 | 12 | DLBCL (7) Small cleaved (2) Mixed (3) | 4 of 12 | 1 of 12 | CHOP (4) | 4 of 12 | 2 relapsed or died (NR) | 1 NR (Received chemo, RT NR) | 2 died – mean survival 13 months | 3 died – mean survival 26 months (5 died after RT only – mean survival 22 months) |
Ezzat Saudi Arabia | 1996 | 5 | DLBCL (5) | 2 of 5 | 1 of 5 | CHOP (4) CHOP- Bleo (1) | 2 of 5 | 0 | 1 alive at 23 months (Received CHOP, 0 RT) | 2 alive at 24,24 months | 2 alive at 30,84 months |
Bouvet USA | 1997 | 11 | DLBCL (10) Mixed follicular (1) | 6 of 11 | 3 of 11 | See legend* | 7 of 11 | 0 | 3 alive at 11,13,23 months (All received CHOP, OPEN or CHOP-Bleo, 0 RT) | 1 alive at 191 months | 4 alive at 44,55,67,159 months 3 died at 12,16,80 months |
Koniaris USA | 2000 | 8 | DLBCL (7) Mixed follicular (1) | 3 of 8 | 3 of 8 | CHOP (6) MACOP-B (1) | 5 of 8 | 0 | 3 alive at 53,62,64 months (2 received CHOP and RT) | 1 alive at 24 months | 2 alive at 51,128 months 2 died at 9,37 months |
Nishimur a Japan | 2001 | 19 | DLBCL (9) B Immunocytoma (2) B follicular (2) T peripheral (3) T anaplastic large (1) | 2 of 19 | 10 of 19 | CHOP (5) Mitomycin (1) Tegafur (1) Unspecified chemo (1) | 0 of 19 | 7 died at 1,2,2,3,8,60,72 months | 4 died at 9,10,11,27 months 4 alive at 3,4,12,19 months 2 ND (6 received chemo, 4 no chemo, 0 RT) | 2 died at 2,8 months | 0 |
Nayer USA | 2004 | 8 | DLBCL (4) High grade B cell (1) Low grade B (2) Suspicious (1) | 8 of 8 | 0 of 8 | Chemo (4) Chemo and auto SCT (2) NR (2) | 3 of 8 (2 NR) | 0 | 0 | 3 alive at 5,6,76 months | 3 alive at 2,7,72 months |
Arcari Italy | 2005 | 5 | DLBCL (3) Lymphoplasmacytic (2) | 3 of 5 | 2 of 5 | CVP/CHO P (3) CHOP (1) CVP (1) | 2 of 5 | 0 | 1 alive at 160 months 1 died at 8 months (Received CHOP or CVP, 0 RT) | 1 alive at 60 months 2 died at 67, 88 months (2 of 3 received RT) | |
Grimison Australia [current series] | 2005 | 4 | DLBCL (3) Follicular (1) | 1 of 4 | 0 of 4 | CHOP (2) Rituximab- CHOP (1) CVP (1) | 4 of 4 | 0 | 0 | 0 | 1 died 32 months 3 alive 15,25,64 months |
Overall | 107 cases inc. current series | Excluding 2 NR: 29 of 105 | 23 of 107 | 80 of 107 | Excluding 2 NR: 33 of 105 | Excluding 2 NR: 0% (0 of 15) NED Mean 13 months 2YS 13% (2 of 15) | Excluding 5 NR: 72% (13 of 18) NED Mean 34 months 2YS 33% (6 of 18) | 57% (36 of 63) NED Mean 38 months 2YS of 62% (28 of 45) – excludes 18 NR | |||