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Table 2 Alterations of the expression of oncogenes and tumor suppressors in C3H cells during mycoplasmal induced malignant transformation

From: Alteration of gene expression profiles during mycoplasma-induced malignant cell transformation

Gene/Protein Name Classification   Change of the expression at different stages
   GenBank 1 wk 11 wks 18 wks
Casitas B-lineage lymphoma Oncogene X57111    2.23
Villin 2 Oncogene X60671    2.15
FBJ osteosarcoma oncogene Tumor suppressor V00727    Down
G-protein coupled receptor 25 Oncogene U39827 Up Up Up
Chemokine-like receptor 1 Oncogene U79525 Up Up Up
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Tumor suppressor AJ011739   0.49  
Notch gene homolog 4 (Drosophila) Oncogene M80456   Down  
Lymphoid blast crisis-like 1 Oncogene U28495    Up
Myeloblastosis oncogene-like 1 Oncogene L35261   Down  
Myeloblastosis oncogene-like 2 Oncogene X70472 3.20 2.94  
Neurofibromatosis 2 Tumor suppressor L27105    2.65
Retinoblastoma-like 1 (p107) Tumor suppressor U27177   Down  
Transformation related protein 53 Tumor suppressor K01700 0.39 0.22 0.42
RAB17, member RAS oncogene family Oncogene X70804   Up  
RAB24, member RAS oncogene family Oncogene Z22819   Up Up
Src homology 2 domain-containing transforming protein C1 Oncogene U15784   Down  
SKI-like Oncogene U36203   Down  
Vav 1 oncogene Oncogene X64361   Up Up
  1. 1. The comparison was made by dividing the gene expression level in control cells by that in cells infected with mycoplasmas for 1 week (wk), 11 weeks or 18 weeks (wks).
  2. 2. The ratio ≥ 2.0 or ≤ 0.5 was defined as a significant increase or decrease when expression levels of a given gene in both samples were greater than the cutoff level, 5000 density units.
  3. 3. "Up" means that the adjusted intensity of a gene in control cells is below 5000 units (a cutoff line for expression), while the adjusted intensity of this gene in mycoplasma infected cells was 5000 units above the cutoff level. The meaning of "Down" is vise verse. The blank means no significant change.