Alteration of gene expression profiles during mycoplasma-induced malignant cell transformation

BMC Cancer

Table 2 Alterations of the expression of oncogenes and tumor suppressors in C3H cells during mycoplasmal induced malignant transformation

Gene/Protein Name	Classification		Change of the expression at different stages
		GenBank	1 wk	11 wks	18 wks
Casitas B-lineage lymphoma	Oncogene	X57111			2.23
Villin 2	Oncogene	X60671			2.15
FBJ osteosarcoma oncogene	Tumor suppressor	V00727			Down
G-protein coupled receptor 25	Oncogene	U39827	Up	Up	Up
Chemokine-like receptor 1	Oncogene	U79525	Up	Up	Up
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Tumor suppressor	AJ011739		0.49
Notch gene homolog 4 (Drosophila)	Oncogene	M80456		Down
Lymphoid blast crisis-like 1	Oncogene	U28495			Up
Myeloblastosis oncogene-like 1	Oncogene	L35261		Down
Myeloblastosis oncogene-like 2	Oncogene	X70472	3.20	2.94
Neurofibromatosis 2	Tumor suppressor	L27105			2.65
Retinoblastoma-like 1 (p107)	Tumor suppressor	U27177		Down
Transformation related protein 53	Tumor suppressor	K01700	0.39	0.22	0.42
RAB17, member RAS oncogene family	Oncogene	X70804		Up
RAB24, member RAS oncogene family	Oncogene	Z22819		Up	Up
Src homology 2 domain-containing transforming protein C1	Oncogene	U15784		Down
SKI-like	Oncogene	U36203		Down
Vav 1 oncogene	Oncogene	X64361		Up	Up

1. The comparison was made by dividing the gene expression level in control cells by that in cells infected with mycoplasmas for 1 week (wk), 11 weeks or 18 weeks (wks).
2. The ratio ≥ 2.0 or ≤ 0.5 was defined as a significant increase or decrease when expression levels of a given gene in both samples were greater than the cutoff level, 5000 density units.
3. "Up" means that the adjusted intensity of a gene in control cells is below 5000 units (a cutoff line for expression), while the adjusted intensity of this gene in mycoplasma infected cells was 5000 units above the cutoff level. The meaning of "Down" is vise verse. The blank means no significant change.

ISSN: 1471-2407