Figure 1

Survival of and tumour multiplicity within each of the cohort. Survival of (A), tumour type (B), intestinal adenoma number (C) and size (D) in Mlh1 ^-/- PPARδ^+/+, Mlh1 ^-/- PPARδ^+/-, and Mlh1 ^-/- PPARδ^-/- mice. KaplañMeier plot (A) showing the age of each animal at the time of death: Solid line, Mlh1 ^-/- PPARδ^+/+ (n = 20); dashed line, Mlh1 ^-/- PPARδ^+/- (n = 20); broken line, Mlh1 ^-/- PPARδ^-/- (n = 16). Pie charts (B) indicate the type identified at death in each mouse. Grey slice, mice with lymphoma; white slice, mice with akanthoma; striped slice, mice with dysplastic cysts; black slice, mice with Hemangiosarcomas. Box plots showing the number (combining small and large intestine) (C) or size (D) of intestinal adenomas per mouse at death. Intestinal preparations were collected from animals, fixed and tumours in the small and large intestine were counted and sized (expressed as width by length). Boxes encompass the first quartile (at bottom) to the third quartile (at top) of the data set; the horizontal boxed line represents the median; the asterisks represent outliers.