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Table 1 The ER status, AIB1 amplification, and poly Q encoding sequences in breast cell lines

From: AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines

Cell line a

ER status

AIB1 copy number ratio (tumor/normal)

Number of sequence patterns

MCF-10A

-

1.1

3

MCF-10A neo

-

1.3

3

A1N4 b

-

2.0

2

AK-47

-

1.4

3

MDA-MB435

-

1.3

4

LCC6

-

2.0

7

MDA-MB157

-

1.1

6

MDA-MB134V

-

1.4

2

MDA-MB231N

-

1.2

2

HBL100

-

1.2

1

ZR-75-30

-

1.7

1

HS 578T

-

1.9

2

HS 578BST

-

1.1

2

MCF7

+

22.2

1

MCF-7 P19

+

18.7

3

MCF-7 P72

+

22.8

3

LY-2

+

19.9

2

R27

+

19.4

2

LCC1

+

13.5

3

LCC2

+

14.6

2

LCC9

+

15.6

2

BT474

+

4.9

2

BT-483

+

1.9

4

BT20

+

1.7

2

MDA-MB468

+

1.7

2

ZR-75-1

+

1.5

2

MDA-MB361

+

1.3

2

T47D

+

1.0

5

MDA-MB330

+

0.9

2

  1. aLCC1: estrogen independent and responsive which is selected for growth in vivo without estrogens; LCC2: selected from LCC1 by treatment with 4-OH TAM; LCC9: selected from LCC1 by treatment with ICI 182780, resistant to ICI182780 and 4-OH TAM:, LY-2: selected for resistance to 4-OH TAM, KEO and LY 117018; R27: able to grow in the presence of 4-OH TAM. LCC6 is the more aggressive variant of MD-MB435. AK-47 is the variant derived from ZR-75-1. A1N4 is a normal breast cell line.
  2. bCell lines listed in Table 2 are in bold.
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BMC Cancer

ISSN: 1471-2407

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