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Table 1 The ER status, AIB1 amplification, and poly Q encoding sequences in breast cell lines

From: AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines

Cell line a ER status AIB1 copy number ratio (tumor/normal) Number of sequence patterns
MCF-10A - 1.1 3
MCF-10A neo - 1.3 3
A1N4 b - 2.0 2
AK-47 - 1.4 3
MDA-MB435 - 1.3 4
LCC6 - 2.0 7
MDA-MB157 - 1.1 6
MDA-MB134V - 1.4 2
MDA-MB231N - 1.2 2
HBL100 - 1.2 1
ZR-75-30 - 1.7 1
HS 578T - 1.9 2
HS 578BST - 1.1 2
MCF7 + 22.2 1
MCF-7 P19 + 18.7 3
MCF-7 P72 + 22.8 3
LY-2 + 19.9 2
R27 + 19.4 2
LCC1 + 13.5 3
LCC2 + 14.6 2
LCC9 + 15.6 2
BT474 + 4.9 2
BT-483 + 1.9 4
BT20 + 1.7 2
MDA-MB468 + 1.7 2
ZR-75-1 + 1.5 2
MDA-MB361 + 1.3 2
T47D + 1.0 5
MDA-MB330 + 0.9 2
  1. aLCC1: estrogen independent and responsive which is selected for growth in vivo without estrogens; LCC2: selected from LCC1 by treatment with 4-OH TAM; LCC9: selected from LCC1 by treatment with ICI 182780, resistant to ICI182780 and 4-OH TAM:, LY-2: selected for resistance to 4-OH TAM, KEO and LY 117018; R27: able to grow in the presence of 4-OH TAM. LCC6 is the more aggressive variant of MD-MB435. AK-47 is the variant derived from ZR-75-1. A1N4 is a normal breast cell line.
  2. bCell lines listed in Table 2 are in bold.