Table 5 Genes regulated by SSeCKS in v-Src transformed cells^a A value ≥ 2 represents induction; a value ≤ 0.5 represents repression

Signal transduction

   Cytokine inducible kinase

   G protein-coupled receptor 56

   Guanine nucleotide binding protein (G protein), gamma 2 subunit

   Protein tyrosine phosphatase, non-receptor type 11

   Serine/threonine kinase 4

   RAB20, member RAS oncogene family

   Phosphatidylinositol-4-phosphate 5-kinase, type 1 beta

   Growth arrest and DNA-damage-inducible 45 alpha

   Butyrate-induced transcript 1

   Suppressor of cytokine signaling 3

   Serine/arginine-rich protein specific kinase 2

   Mitogen activated protein kinase kinase 6

   Regulator of G-protein signaling 2

   Ras and Rab interactor 2

   Dual specificity phosphatase 10

   Myristoylated alanine rich protein kinase C substrate

Cell cycle and transcriptional regulator

   Histone 1, H2bp

   Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

   Retinoblastoma binding protein 7

   Histone 2, H3c2

   v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F

   Inhibitor of DNA binding 2

   Transcription factor AP-4 (activating enhancer-binding protein 4)

   Cell division cycle 20 homolog (S. cerevisiae)

   Basic helix-loop-helix transcription factor 6

   High mobility group box 3

   Hypoxia inducible factor 1, alpha subunit

   Kruppel-like factor 7 (ubiquitous)

Growth factor and receptor

   Chemokine (C-C motif) ligand 2

   Nerve growth factor, beta

   Glial cell line derived neurotrophic factor family receptor alpha 1

   Interleukin 1 receptor-like 1

   Platelet derived growth factor receptor, beta polypeptide

   Transforming growth factor, beta 2

Others

   S100 calcium binding protein A8 (calgranulin A)

   Fatty acid desaturase 3

   Heat shock protein 4

   Deubiquitinating enzyme 1

   alpha fetoprotein

   Tissue inhibitor of metalloproteinase 3

   HIF-1 responsive RTP801

   5-azacytidine induced gene 1

   Growth differentiation factor 5

   Growth arrest specific 1

   Caspase 7

   retinitis pigmentosa 1 homolog (human)

   protocadherin 18