SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis

Table 4 Genes regulated by ts72v-Src activation A value ≥ 2 represents induction; a value ≤ 0.5 represents repression

		Modulation
Gene	*Symbol*	A	B
Signal Transduction
regulator of G-protein signaling 16	Rgs16	10.13	12.70
suppressor of cytokine signaling 3	Socs3	3.89	3.00
paternally expressed 3	Peg3	3.22*	3.50*
protein kinase, cGMP-dependent, type II	Prkg2	2.53	2.30
insulin-like growth factor binding protein 4	Igfbp4	0.15**	0.42**
SH3-domain binding protein 5 (BTK-associated)	Sh3bp5	NC	0.29
ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3	Centd3	0.08	0.05
Cell cycle and transcriptional regulator
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F	Maff	17.03	3.00
high mobility group AT-hook 2	Hmga2	6.96	5.00
runt related transcription factor 1, RUN X1/AML-1	Runx1	6.77	5.50
ets variant gene 4 (E1A enhancer binding protein, E1AF)	Etv4	6.68	8.30
fos-like antigen 1	Fosl1	4.47*	2.80*
high mobility group box 3	Hmgb3	3.73*	3.30*
transcription factor EC	Tcfec	NC	63.00
inhibitor of DNA binding 4	Id4	0.22	NC
inhibitor of DNA binding 2	Id2	NC	0.43
basic helix-loop-helix transcription factor 6	Atoh8	0.15	0.29
Growth factor and receptor
glial cell line derived neurotrophic factor family receptor alpha 1	Gfra1	4.17*	7.00*
interleukin 1 receptor-like 1	Il1rl1	4.20*	3.50*
Others
pleckstrin homology, Sec7 and coiled-coil domains, binding protein	Pscdbp	4.08	3.30
alpha fetoprotein	Afp	3.89*	3.80*
spondin 2, extracellular matrix protein	Spon2	0.13	0.23
carbonyl reductase 2	Cbr2	0.11	0.07

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