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Table 3 Genes Regulated by SSeCKS in NIH3T3 fibroblastsa A value ≥ 2 represents induction; a value ≤ 0.5 represents repression

From: SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis

Gene

Symbol

Modulation

Signal transduction

  

   G protein-coupled receptor 56

Gpr56

126.24*

   BTB (POZ) domain containing 2

Btbd2

10.85

   Guanine nucleotide binding protein (G protein), gamma 2 subunit

Gng2

9.58*

   Ras association (RalGDS/AF-6) domain family 5

Rassf5

8.75

   Calcium binding protein 2

Cabp2

8.11

   Butyrate-induced transcript 1

Ptplad1

4.08*

   Signal-transducing adaptor protein-2

Stam2

3.20

   Protein kinase C, epsilon

Prkce

2.36

   Interferon-stimulated protein

G1p2

2.30

   Tnf receptor-associated factor 6

Traf6

2.23

   RAB33B, member of RAS oncogene family

Rab33b

2.17

   Insulin-like growth factor 2, binding protein 3

Igf2bp3

0.49

   Myristoylated alanine rich protein kinase C substrate

Marcks

0.48*

   Insulin-like growth factor binding protein 4

Igfbp4

0.47

   N-myc downstream regulated 1

Ndrg1

0.41

   Paternally expressed 3

Peg3

0.27

   Dual specificity phosphatase 9

Dusp9

0.15

Cell cycle and transcriptional regulator

  

   Retinoblastoma 1

Rb1

3.48

   c-myc binding protein

Mycbp

3.41

   Histone 2, H2aa1

Hist2h2aa1

3.07

   Histone 3, H2a

Hist3h2a

2.99

   Zinc fingers and homeoboxes protein 1

Zhx1

2.79

   Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

Cdkn2d

2.73*

   CCAAT/enhancer binding protein (C/EBP), beta

Cebpb

0.50

   Cyclin F

Ccnf

0.48

   Cyclin A2

Ccna2

0.47

   High mobility group box 1

Hmgb1

0.46

   cell division cycle 20 homolog (S. cerevisiae)

Cdc20a

0.46*

   Cyclin B1

Ccnb1

0.44

   LIM domain only 4

Lmo4

0.44

   Fos-like antigen 1

Fosl1

0.41

   Cyclin D1

Ccnd1

0.37

   High mobility group box 3

Hmgb3

0.24*

   Nuclear autoantigenic sperm protein (histone-binding)

Nasp

0.06

Cytoskeleton

  

   Synaptonemal complex protein 3

Sycp3

8.34

   Microtubule-associated protein 7

Mtap7

0.18

Growth factor and receptor

  

   Transforming growth factor, beta 1

Tgfb1

2.33

   Nerve growth factor, beta

Ngfb

2.28*

   Transforming growth factor alpha

Tgfa

2.27

   Platelet derived growth factor receptor, beta polypeptide

Pdgfrb

0.30*

   Interleukin 1 receptor-like 1

Il1rl1

0.29*

   Glial cell line derived neurotrophic factor family receptor alpha 1

Gfra1

0.15*

Others

  

   Alpha fetoprotein

Afp

0.32*

  1. aS24 MEF, 37°C, Tet (-) vs (+)
  2. * Similar effects after SSeCKS re-expression in v-Src transformed cells (Table 5).