Figure 1

Treatment design via two interacting cycles, one in which models are developed iteratively through predictions followed by experimental validations, and a second in which control systems are developed iteratively through comparisons of new design performances in controller-model combined simulations. As these cycles evolve, the current best control law will be the current best proposal for a state feedback based clinical trial. The trials will be individualized via polymorphism-based model parameter perturbations and differences in initial states.