Figure 3From: Differential regulation of NF-κB activation and function by topoisomerase II inhibitorsMitoxantrone and aclarubicin but not ICRF-193, repress NF-κB reporter plasmid activity. U-2 OS cells were transfected with 2 μg of 3 × κB ConA luciferase reporter plasmid and 36 hours later stimulated with 4 μM ICRF-193, 1 μM aclarubicin or 2.5 μM mitoxantrone for 8 hours. Results are normalised such that no change in luciferase activity has a value of 0.Back to article page