Table 1 Results of Guthrie cards screening in patients with ALL
From: Prenatal origin of childhood AML occurs less frequently than in childhood ALL
Patient | Molecular marker | Detection sensitivity | % blasts at diagnosis | Age at diagnosis | Guthrie card |
|---|---|---|---|---|---|
ALL1 | Vd2 | 10-4 | N.A. | 2 y 8 mo | negative |
VH3 | 10-5 | negative | |||
ALL2 | VH3 | 10-4 | 50% | 3 y 3 mo | negative |
TEL/AML1 | 10-4-10-5 | negative | |||
ALL3 | VgI | 10-5 | >55% | 4 y 5 mo | positive |
VkIA | 10-4 | negative | |||
ALL4 | Vd2 | 10-5 | N.A. | 3 y 6 mo | positive |
VH3 | 10-4 | positive | |||
ALL5 | VH3 | 10-5 | 70% | 4 y | negative |
ALL6 | VH3 | 10-4 | 84% | 1 y 8 mo | negative |
VH1 | 10-5 | negative | |||
ALL7 | VH1 | 10-5 | 83% | 3 y 3 mo | negative |
ALL8 | VH3 | 10-4 | 79% | 2 y 6 mo | negative |
ALL9 | VH3 | 10-4 | 89% | 2 y 3 mo | negative |
VH4 | 10-5 | negative | |||
ALL10 | VgI | 10-4 | >30% | 3 y 9 mo | negative |
ALL11 | TEL/AML1 | 10-4-10-5 | 80% | 5 y 7 mo | negative |
ALL12 | TEL/AML1 | 10-5 | 77% | 3 y 6 mo | positive |