Figure 1From: Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation Schematic genomic structure of the IGFBP3 gene. There exist 11 p53 consensus sequences upstream of the promoter [16] and two binding sites in introns [3]. Polymorphisms and hypermethylations are identified in the promoter upstream p53 binding sites [26, 12].Back to article page