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Table 2 Dose-limiting toxicities (DLTs) according to dose level.

From: Phase I dose-escalating study of docetaxel in combination with 5-day continuous infusion of 5-fluorouracil in patients with advanced gastric cancer

Dose level (5-FU/day) Pts/cycles After first cycle After all courses (pts/cycles)
    Neutropenia FN1 stomatitis diarrhea asthenia
Level 1 (250 mg) 3/4 None    1/1   1/1
Level 2 (500 mg) 10/35 Stomatitis (1) 4/5   6/11 1/1 4/7
Level 3 (750 mg) 3/4 Stomatitis (1)
FN (1)
2/2 1/1 2/2 1/1 1/1
  1. 1 FN denotes febrile neutropenia.