Figure 4

Hierarchical clustering diagram at 1, 12 and 24 hrs. A set of 2054 genes which show significant changes in expression in at least one of the time points in either of the two cell line clustered using the standard correlation. Cluster of the corresponding time points for each cell line indicates very close similarity of NHEK and Caco-2 at time point 1 hr, at which the NAC effect is not yet pronounced (both cell lines form a tight separate cluster at 1 hr). However, during the later time points the changes are much more significant and the differences between Caco-2 and NHEK become very pronounced as well (each cell line forms a separate cluster that includes both 12 and 24 hrs time points).