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Table 2 Distribution of the probesets affected by the various drugs to categories of the GO biological categories.

From: Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways

 

actinomycin D

doxorubicin

vincristine

HG-U133A

Total number of probesets in target list

3309

1019

134

22215

Total number of probesets with annotated biological process

2158

702

87

13704

Physiological process

    

   Cell growth and/or maintenance

827***

262*

40*

4701

Cell proliferation

367***

123***

14

1576

Cell cycle

290***

87***

10

1085

   Death

151***

39

5

682

   Metabolism

1507***

429

50

8247

Regulation of biological process

    

   Regulation of programmed cell death

87***

22

2

400

Anti-apoptosis

41***

5

2

152

Positive regulation of apoptosis

50*

10

0

231

   Regulation of signal transduction

49*

13

3

242

I-κB kinase/NF-κB cascade

29*

7

2

123

   Regulation of metabolism

509***

121

22*

2398

Protein biosynthesis

54***

6

1

156

Nucleobase, nucleoside, nucleotide synthesis

455***

111

21*

2232

Negative regulation of nucleobase, nucleoside, nucleotide and nucleid acid metabolism

49***

8

2

180

DNA metabolism

15**

1

0

50

  1. Based on the 'Gene Ontology Standard Vocabulary' the probesets affected by actinomycin D, doxorubicin and vincristine were sorted according to the 'Biological Process' into the indicated major categories. The number of probesets with annotated biological processes is given and corresponds to approximately 66% of the probesets affected. The two major categories investigated are shown in bold and subcategories of the previous process are indicated by offset. As a reference the distribution of all annotated probesets of the HG-U133A array to the same categories are listed. Genes significantly overrepresented in the target lists were identified using the statistics (hypergeometric distribution) implemented in the 'GO browser' of Spotfire DecisionSite for Functional Genomics. *, ** and *** indicate p-values of p < 0.05, p < 0.01, and p < 0.001, respectively.