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Table 1 Patient Characteristics and their corresponding hazard ratios*

From: Familial breast cancer: characteristics and outcome of BRCA 1–2 positive and negative cases

CHARACTERISTICS OF PATIENTS

BRCA-WT (n = 86)

BRCA+ (n = 29)

p-value#

Hazard Ratio (95% CI)

Average age in years (range)

45.3 (22–82)

42.3 (26–62)

_

_

Laterality (right/left/bilat)+

35/41/5

15/13/1

0.68

1.3 (0.1–5.7)

Premenopausal

53/81 (65%)

23/29 (79%)

0.17

1.9 (0.5–6.7)

T3-T4

8/83 (10%)

3/23 (13%)

0.64

1.2 (0.3–6.5)

N+

37/76 (49%)

17/27 (63%)

0.20

1.4 (0.5–4.6)

G3

31/77 (40%)

19/25 (76%)

0.002

2.6 (0.8–7.2)

Multifocal-multicentric

38/82 (46%)

8/24 (33%)

0.26

0.8 (0.1–3.7)

ER-

20/70 (29%)

10/23 (43%)

0.18

1.5 (0.4–5.1)

Pgr-

22/72 (31%)

8/23 (35%)

0.71

1.1 (0.2–6.7)

HER2 2+/3+

11/31 (35%)

2/13 (15%)

0.18

0.6 (0.02–4.9)

  1. *analyses stratified according to age (one-year age group) and tumour grade
  2. # univariate chi-square
  3. + Hazard Ratio not computed for bilaterality