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Table 1 Patient Characteristics and their corresponding hazard ratios*

From: Familial breast cancer: characteristics and outcome of BRCA 1–2 positive and negative cases

CHARACTERISTICS OF PATIENTS BRCA-WT (n = 86) BRCA+ (n = 29) p-value# Hazard Ratio (95% CI)
Average age in years (range) 45.3 (22–82) 42.3 (26–62) _ _
Laterality (right/left/bilat)+ 35/41/5 15/13/1 0.68 1.3 (0.1–5.7)
Premenopausal 53/81 (65%) 23/29 (79%) 0.17 1.9 (0.5–6.7)
T3-T4 8/83 (10%) 3/23 (13%) 0.64 1.2 (0.3–6.5)
N+ 37/76 (49%) 17/27 (63%) 0.20 1.4 (0.5–4.6)
G3 31/77 (40%) 19/25 (76%) 0.002 2.6 (0.8–7.2)
Multifocal-multicentric 38/82 (46%) 8/24 (33%) 0.26 0.8 (0.1–3.7)
ER- 20/70 (29%) 10/23 (43%) 0.18 1.5 (0.4–5.1)
Pgr- 22/72 (31%) 8/23 (35%) 0.71 1.1 (0.2–6.7)
HER2 2+/3+ 11/31 (35%) 2/13 (15%) 0.18 0.6 (0.02–4.9)
  1. *analyses stratified according to age (one-year age group) and tumour grade
  2. # univariate chi-square
  3. + Hazard Ratio not computed for bilaterality