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Table 4 Comparison of difference in gene expression between combination treatment and mono-treatment in PC3 cells

From: Gene expression profiling revealed novel mechanism of action of Taxotere and Furtulon in prostate cancer cells

Gene Taxotere+Furtulon
  6 h 36 h 72 h
Decrease in combination treatment, No change or increase in mono-treatment.    
NM_001261.1 cyclin-dependent kinase 9 (CDC2-related kinase) (CDK9) -1.3 -1.2 -2.3
NM_016507.1 CDC2-related protein kinase 7 (CrkRS) NC -1.6 -2.3
AF080157.1 IkB kinase-a (IKK-alpha) NC -2.0 -1.6
U62296.1 transcription factor NF-YC -1.1 -1.7 -2.3
BC005003.1 nuclear transcription factor Y, gamma -1.1 -2.0 -2.1
BC001771.1 transcription factor IIF NC -1.6 -2.3
AI434345 activating transcription factor 1 NC -2.5 -2.6
BC001173.1 eukaryotic translation initiation factor 3 NC -1.3 -2.0
U78525.1 eukaryotic translation initiation factor (eIF3) NC -1.4 -2.0
NM_001814.1 cathepsin C (CTSC) NC -1.3 -2.0
NM_003377.1 vascular endothelial growth factor B (VEGFB) -2.1 NC NC
AF035620.1 BRCA1-associated protein 2 (BRAP2) -2.3 NC NC
AF035620.1 BRCA1-associated protein 2 (BRAP2) -2.3 -2.0 -1.4
NM_005346.2 heat shock 70 kD protein 1B (HSPA1B) -1.1 -2.1 -1.1
BC000478.1 heat shock 70 kD protein 9B NC -1.7 -2.3
NM_014278.1 heat shock protein (hsp110 family) (APG-1) -1.2 -1.3 -2.0
BC002526.1 Similar to heat shock protein, 110 kDa -1.1 -1.4 -2.1
Increase in combination treatment, No change or decrease in mono-treatment.    
NM_000077.1 cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4) NC 1.7 2.1
NM_001262.1 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) NC 2.1 2.0
J03202.1 laminin B2 chain mRNA NC 1.3 2.0
BG164365 microtubule-associated protein 1B NC 2.3 2.0
NM_000594.1 tumor necrosis factor, member 2 NC 2.5 1.6
NM_001065.1 tumor necrosis factor, member 1A NC 2.0 1.9
BC000125.1 Similar to transforming growth factor, beta 1 -1.2 1.9 2.1
NM_005649.1 transcription factor 17 (TCF17) NC 1.1 2.3
NM_005923.2 mitogen-activated protein kinase kinase kinase 5 (MAP3K5) NC 1.6 2.1
NM_005204.1 mitogen-activated protein kinase kinase kinase 8 (MAP3K8) NC 2.3 4.3
NM_000785.1 cytochrome P450, subfamily XXVIIB NC 2.1 1.5
NM_002960.1 S100 calcium-binding protein A3 (S100A3) NC 2.5 2.5
NM_002962.1 S100 calcium-binding protein A5 NC 8.6 10.6
  1. NC: No change; Negative value: Decrease; Positive value: Increase.
  2. The genes in this list showed a >2 fold change in expression in at least one time point in combination treatment.