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Table 2 Fold change of genes in PC3 cells exposed to combination treatment or mono-treatment with Taxotere or Furtulon

From: Gene expression profiling revealed novel mechanism of action of Taxotere and Furtulon in prostate cancer cells

Gene Taxotere Furtulon Taxotere+Furtulon
  6 h 36 h 72 h 6 h 36 h 72 h 6 h 36 h 72 h
Cell cycle and apoptosis          
NM_001237.1 cyclin A2 (CCNA2) NC -1.1 -2.0 -1.1 -1.7 -3.0 -1.1 -1.4 -2.5
BE407516 cyclin B1 -1.1 -1.1 -2.3 NC -3.0 -6.1 -1.1 -3.0 -5.3
NM_001761.1 cyclin F (CCNF) -1.3 -1.3 -2.5 -1.5 -2.5 -2.6 -1.6 -1.6 -2.5
NM_014303.1 pescadillo homolog 1 NC -1.5 -2.3 1.3 -1.9 -2.6 -1.1 -2.1 -3.5
NM_003132.1 spermidine synthase (SRM) NC -1.5 -2.5 -1.1 -1.3 -2.5 -1.1 -1.1 -2.3
NM_000389.1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.7 1.0 2.6 1.9 2.6 3.5 NC 1.7 3.5
NM_003914.1 cyclin A1 (CCNA1) 1.3 2.3 2.8 NC 1.5 2.5 NC NC 2.0
L49506.1 cyclin G2 -2.1 2.0 2.6 -2.8 2.3 2.3 NC 3.7 2.5
NM_004354.1 cyclin G2 (CCNG2) -1.9 3.0 3.2 NC 2.5 2.3 1.0 4.6 3.5
AL535380 B-cell translocation gene 1, anti-proliferative 1.1 1.7 3.5 NC 1.4 2.8 -1.5 1.6 2.6
NM_006472.1 upregulated by 1,25-dihydroxyvitamin D-3 (VDUP1) 1.3 2.1 -2 1.0 2.1 2.3 1.0 2.3 NC
NM_015675.1 growth arrest and DNA-damage-inducible, beta (GADD45B) 1.2 2.5 6.5 1.6 1.5 2.6 1.0 NC 3.5
AF087853.1 growth arrest and DNA damage inducible protein beta NC 2.0 4.6 1.3 1.2 2.3 NC NC 3.2
AF078077.1 growth arrest and DNA-damage-inducible protein GADD45beta 1.5 2.0 5.3 1.1 1.2 2.1 NC 1.4 2.8
Transcription and translation          
NM_007111.1 transcription factor Dp-1 (TFDP1) NC -1.6 -3.2 -1.3 -1.1 -2.0 NC -1.1 -2.0
NM_012068.2 activating transcription factor 5 (ATF5) NC -2.1 -3.5 NC -1.5 -2.1 -1.3 -1.1 -2.6
NM_012251.1 transcription factor A, mitochondrial (TFAM) 1.3 -1.5 -2.5 NC -1.6 -2.0 -1.1 -2.0 -3.7
AF220509.1 transcription associated factor TAFII31L NC -2.3 -3.2 -1.3 -1.3 -2.3 NC -1.2 -5.7
AA393940 eukaryotic translation initiation factor 5A -1.3 -1.5 -3.0 -1.6 -2.0 -3.5 -1.1 -1.1 -2.0
NM_001674.1 activating transcription factor 3 (ATF3) 1.4 1.9 14.9 1.5 2.1 3.5 1.1 2.6 4.9
Oncogenesis and other          
NM_001511.1 GRO1 oncogene (GRO1) 2 -1.5 -3.0 1.7 1.2 -2.0 NC NC -4.0
NM_002090.1 GRO3 oncogene (GRO3) 2.8 -3.0 -4.0 2.5 -1.4 -6.5 NC -2.8 -13.9
NM_005754.1 Ras-GTPase-activating protein SH3-domain-binding protein NC -1.7 -2.8 NC -2.0 -2.5 NC -2.6 -4.6
NM_000026.1 adenylosuccinate lyase (ADSL) NC -1.3 -2.5 NC -1.4 -2.6 NC -1.6 -3.0
M80261.1 apurinic endonuclease (APE) -1.1 -1.4 -3.0 -1.1 -1.9 -2.6 NC -2.1 -3.7
D13413.1 tumor-associated 120 kDa nuclear protein p120 -1.1 -2.0 -3.2 -1.7 -1.7 -2.5 -2.3 -1.1 -3.0
AI743685 methionine aminopeptidase; eIF-2-associated p67 NC -2.6 -2.0 1.5 -1.5 -3.2 NC -2.3 -2.8
NM_002634.2 prohibitin (PHB) NC -1.4 -3.0 NC -1.9 -2.1 NC -1.5 -2.6
NM_002546.1 osteoprotegerin 1.5 -1.3 -3.0 1.2 -2.1 -3.0 NC -2.8 -5.3
AF003934.1 prostate differentiation factor mRNA -1.5 4.3 26.0 -1.7 4.9 16.0 NC 4.3 12.1
NM_000177.1 gelsolin (amyloidosis, Finnish type) (GSN) NC 1.5 2.8 NC 2.0 3.5 NC 1.9 2.3
Invasion and metastasis          
NM_003254.1 tissue inhibitor of metalloproteinase 1 (TIMP1) NC 2.0 2.5 NC 2.6 3.7 NC 2.6 3.7
NM_003255.2 tissue inhibitor of metalloproteina(TIMP2) NC 1.6 2.5 NC 2.3 3.5 NC 1.6 3.5
NM_002638.1 protease inhibitor 3 (PI3) 1.2 2.0 2.0 1.1 3.7 5.7 1.0 3.0 4.6
NM_005562.1 laminin, gamma 2 (nicein (100 kD) 1.3 1.5 2.0 1.1 2.5 3.7 NC 2.3 3.7
NM_001908.1 cathepsin B (CTSB) NC 1.7 3.0 NC 1.7 2.8 1.1 1.3 2.5
NM_002658.1 plasminogen activator, urokinase (PLAU) NC 2.3 3.5 NC 2.8 2.3 1.0 2.1 1.9
NM_000930.1 plasminogen activator, tissue (PLAT) 1.1 2.5 4.6 NC 5.7 9.8 NC 3.2 4.9
NM_002421.2 matrix metalloproteinase 1 (MMP1) NC 1.4 4.3 NC 4.9 18.4 NC 5.7 13.0
NM_004994.1 matrix metalloproteinase 9 (MMP9) 1.1 1.7 2.0 1.0 1.9 2.0 NC 2.5 2.1
NM_000435.1 Notch homolog 3 (NOTCH3) NC 2.0 2.6 -2 2.3 3.2 NC 3.5 3.5
Resistance to chemotherapeutic agents          
NM_000499.2 cytochrome P450, subfamily I (CYP1A1) 1.4 3.0 4.0 NC 3.5 5.3 1.2 9.2 10.6
NM_006697.1 cisplatin resistance associated (CRA) 1.0 1.7 2.0 -1.3 2.0 2.6 NC NC 2.6
NM_005980.1 S100 calcium-binding protein P (S100P) -1.2 4.9 24.3 1.1 10.6 27.9 NC 6.5 19.7
NM_002961.2 S100 calcium-binding protein A4 (S100A4) 3.0 3.7 5.3 1.0 5.7 11.3 2.8 6.5 10.6
NM_020672.1 S100-type calcium binding protein A14 (LOC57402) NC 1.5 2.0 NC 2.1 2.6 1.1 1.6 2.1
NM_001894.1 casein kinase 1, epsilon (CSNK1E) NC 1.7 3.2 NC 2.0 2.6 1.1 1.7 3.2
NM_000700.1 annexin A1 (ANXA1) NC 1.9 2.3 NC 2.0 2.3 NC 1.6 2.1
  1. The genes in this list showed a >2 fold change in expression in at least one time point in both mono and combination treatment.
  2. NC: No change; Negative value: Decrease; Positive value: Increase.