Figure 2

In situ hybridization of cervical tissue microarrays with CTSF, MMP11 and MMP12 probes. A) Breast cancer (as positive control of CTSF), B) normal cervical epithelium negative for CTSF, C) HSIL with positive immunostaining, D) CC tissue positive for CTSF hybridization, E) Breast cancer (as positive control for MMP11), F) normal cervical epithelium, negative for MMP11 hybridization, G) as in C, HSIL positive for MMP11 hybridization, H) positive hybridization for MMP11 in CC, I) Breast cancer as positive control for MMP12, J) MMP12 negative hybridization in normal epithelium, K) as in C and G HSIL positive for MMP12, and L) Positive hybridization for MMP12 in CC. Original magnifications were 40 X for A, C, E, I and L; and 10X were used for B, D, F, G, H, J, and K.