Figure 4
From: Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity
Light microscopy of hematoxylin and eosin-stained section of representative lungs from controls (A, B) and treatment groups (XRT-WT vs. XRT-TG) at 3 wk (C, D) and 14 wks (E, F). Representative lung sections from XRT-WT exposed to 3 wk of radiation showing mild to moderate damage at 3 wk after radiation (C), which gradually increased with time course of injury and become moderate to severe with increased thickening of alveolar wall and enhanced infiltration composed mainly of macrophages and other inflammatory cells at 14 weeks (E). Whereas the XRT-TG mice showing mild-modest alveolar septal thickness and fewer numbers of alveolar macrophages and other inflammatory cells (D, F). Magnification × 400.