Skip to main content
Figure 3 | BMC Cancer

Figure 3

From: Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells

Figure 3

IKKβKA expression via adenoviral vectors sensitized MCF7 cells to TRAIL-mediated apoptosis. MCF7 cells were infected with increasing doses of adenoviral vectors encoding dominant negative mutant of IKKβ (as shown below each panel), while simultaneous infection with Ad5hTRAIL (as shown above each panel) was performed at a constant MOI of 1000. Cell viability was detected using Molecular Probe's Live/Dead Cellular Viability/Cytotoxicity Kit 48 hours following infection. Numbers represent viral doses applied in MOI values as DNA particles/cell. Fluorescent micrographs are provided in Panel A; Panel B depicts quantitative analysis of such infections. Values represent the mean (± SEM) of three different experiments.

Back to article page