Figure 1From: Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing miceSchematic illustration of replication-defective adenoviral vectors constructed in this study. The E1 region of adenovirus type 5 (Ad 5) was replaced by the indicated genes under the transcriptional control of the immediate early gene promoter from human cytomegalovirus (pCMV). IRES; internal ribosomal entry sequence.Back to article page