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Table 4 PCNA and apoptosis indices and scores of β-catenin, COX-2, iNOS and nitrotyrosine expression in colonic adenocarcinomas.

From: Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands

Group Treatment PCNA-labeling Apoptotic Scores for:
no.   index (%) index (%) β-Catenin COX-2 iNOS Nitrotyrosine
1 AOM/DSS 62.4 ± 13.7a (30) 4.1 ± 1.9 (30) 3.7 ± 0.7 (30) 3.3 ± 0.7 (30) 3.0 ± 1.0 (30) 3.1 ± 0.8 (30)
2 AOM/DSS/0.04% Nimesulide 38.3 ± 11.1 b (6) 11.8 ± 2.9 b (6) 2.3 ± 1.0 c (6) 1.3 ± 0.5 b (6) 1.3 ± 0.5 b (6) 1.7 ± 0.5 b (6)
3 AOM/DSS/0.05% Troglitazone 43.6 ± 9.0 b (9) 10.0 ± 2.4 b (9) 2.7 ± 0.7 c (9) 1.8 ± 0.8 b (9) 1.6 ± 0.5 b (9) 1.8 ± 0.6 b (9)
4 AOM/DSS/0.05% Bezafibrate 40.5 ± 12.7 b (15) 9.7 ± 2.7 b (15) 3.0 ± 0.8 (15) 1.8 ± 0.8 b (15) 1.6 ± 0.6 b (15) 2.2 ± 1.1 b (15)
  1. Numbers in parentheses are numbers of lesions examined.
  2. a : means ± SD.
  3. b,c Significantly different from group 1 by Student's t-test (b P < 0.001 and c P < 0.05).
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