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Table 5 Methylation and gene re-expression of the 12 informative cases.

From: A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes

  

Pre-treat

Post-treat

Re-expression

Gene

dose level

M

U

M

U

Yes/No

DAPK

50

+

-

+

-

No

DAPK

50

+

-

+

-

No

GSTp1

50

+

-

+

-

No

FHIT

100

+

-

+

+

Yes

FHIT

150

+

-

+

+

Yes

MGMT

75

+

-

+

+

Yes

MGMT

150

+

-

+

+

Yes

GSTp1

50

+

-

+

+

Yes

DAPK

75

+

-

-

+

Yes

ER

75

+

-

-

+

Yes

GSTp1

150

+

-

-

+

Yes

GSTp1

75

+

+

-

+

Yes