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Table 1 The distribution of FANCA promoter polymorphism genotypes in breast and ovarian cancer cases and controls

From: A novel duplication polymorphism in the FANCApromoter and its association with breast and ovarian cancer

Study Group No. 11 12 22 12 + 22
   n (%) n (%) n (%) n (%) p valuea ORb (95% CI)
Control 256 112 (43.8) 115 (44.9) 29 (11.3) 144 (56.2)   
All Breast Cancer 352 164 (46.6) 150 (42.6) 38 (10.8) 188 (53.4) 0.51 0.89 (0.64–1.23)
   Diagnosis ≤ 40 years 203 104 (51.2) 79 (38.9) 20 (9.9) 99 (48.8) 0.13 0.74 (0.51–1.07
   Family History 105 39 (37.1) 53 (50.5) 13 (12.4) 66 (62.9) 0.29 1.32 (0.83–2.10)
   Bilateral Disease 44 21 (47.7) 18 (40.9) 5 (11.4) 23 (52.3) 0.63 0.85 (0.45–1.62)
All Ovarian Tumours 390 202 (51.8) 153 (39.2) 35 (9.0) 188 (48.2) 0.05 0.72 (0.53–0.99)
   All Malignant 313 157 (50.2) 126 (40.2) 30 (9.6) 156 (49.8) 0.13 0.77 (0.55–1.08)
Serous 127 62 (48.8) 52 (40.9) 13 (10.2) 65 (51.1) 0.38 0.81 (0.53–1.25)
Endometrioid 82 44 (53.6) 29 (35.4) 9 (11.0) 38 (46.4) 0.13 0.67 (0.41–1.11)
Mucinous 42 23 (54.8) 16 (38.1) 3 (7.1) 19 (45.2) 0.24 0.64 (0.33–1.24)
Clear Cell 13 4 (30.8) 8 (61.5) 1 (7.7) 9 (69.2) 0.40 1.75 (0.52–5.83)
Adenocarcinoma 49 24 (49.0) 21 (42.8) 4 (8.2) 25 (51.0) 0.53 0.81 (0.44–1.49)
   Borderline 15 6 (40.0) 8 (53.3) 1 (6.7) 9 (60.0) 1.00 1.16 (0.40–3.37)
   Benign 62 39 (62.9) 19 (30.6) 4 (6.4) 23 (37.0) 0.007 0.46 (0.26–0.81)
  1. Allele 1 corresponds to the single copy allele, allele 2 corresponds to the duplication allele.
  2. aFisher's exact test (two-sided) for the combined 12/22 genotype frequency using the 11 homozygotes as reference.
  3. bThe odds ratio (OR) and 95% confidence intervals (CI) are shown in parentheses.