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Table 2 Multivariate analysis for Group A

From: The prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy ± chemotherapy

  Local Control Regional Control Disease-free Survival Overall Survival
Parameter    RR    95% CI P value    RR    95% CI P value    RR    95% CI P value    RR    95% CI P value
T1-2 vs. T3-4 1.21 0.58–2.53 0.62 2.74 0.99–7.62 0.05 1.40 0.70–2.83 0.34 3.85 1.46–10.18 0.006
N 0-1-2 vs. N3 3.75 1.47–9.60 0.006 7.68 2.72–21.70 0.0001 5.70 2.34–13.85 0.0001 6.05 2.32–15.77 0.0002
Differentiation 1.50 0.90–2.49 0.12 1.64 0.89–3.02 0.11 1.49 0.93–2.40 0.12 0.81 0.45–1.47 0.49
Perfusion > median 0.55 0.28–1.09 0.09 1.07 0.46–2.51 0.87 0.61 0.32–1.15 0.12 0.65 0.48–0.88 0.28
GLUT-1 & CA IX > median 2.33 1.12–4.82 0.02 2.24 0.97–11.58 0.06 2.06 1.05–4.07 0.04 1.53 0.65–3.60 0.33
  1. Multivariate analysis (Cox proportional hazard model) for Group A towards local control, regional control, disease-free survival and overall survival. Significant P values are marked in bold. RR: relative risk. CI: confidence interval.