Figure 5
From: Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells
Effect of dexamethasone on FAS/CD95-triggered apoptosis. (A) Viability of C6-TK cells after 24 hours of growth in the presence of GCV, sFAS-L, sFAS-L + GCV and DEX + sFAS-L + GCV, assessed with a MTT test. This viability was significantly altered in cells treated with sFAS-L and GCV and this sensitization was abolished by DEX. (B) Viability of LN18-TK cells after 24 hours of growth in the presence of GCV, sFAS-L, sFAS-L + GCV and DEX + sFAS-L + GCV. This viability was significantly altered in cells treated with sFAS-L and GCV and this effect was abolished by DEX. For both cell types, the viability in the absence of any drug was set as 100 percents. (*: P < 0.05, ANOVA). (C) Western blot analysis of the expression of CIAP-2, FAS/CD95 and BCLXL in C6, LN18 and U87 cells following treatment with DEX (1 μM).