Mutations of PIK3CAin gastric adenocarcinoma

BMC Cancer

Table 1 Spectrum of PIK3CA mutations in gastric adenocarcinoma

Case	Nucleotide Substitution^a	Amino acid change	Age	Sex	MSI Status^b,c	KRAS Mutation^c	Tumour site	Tumour type	IM^d
28	A3140G	H1047R	37	M	Stable	-	Body	Intestinal	0
100	G1633A	E545K	79	F	High	-	Antrum	Intestinal	1
240	G1624A	E542K	74	M	High	G12D	Antrum	Intestinal	1
310	A3140G	H1047R	72	F	High	G13D	Antrum	Intestinal	1

^aNucleotide change at the position within coding sequence, where position 1 corresponds to the first position of the start codon
^bHigh, high level of MSI; Stable, microsatellite stable
^cAnalysis of KRAS mutations have been performed and reported previously [16]
^dIM, the presence of intestinal metaplasia at tumour edge; 1, present; 0, absent

ISSN: 1471-2407