Conservation of the Jab1 binding motif in human psoriasin/S100A7 and mouse S100A7/psoriasin Human psoriasin/S100A7 contains a Jab1 binding domain identified previously in p27 and LFA-1. Mouse S100A7/psoriasin also contains the Jab1 binding motif but human S100A15 does not. Note that human S100A15 has a significant change, from a charged (D) to a neutral (T) amino acid, in the first of the essential amino acids (color coded) required for Jab1 binding. The change seen in this residue in the mouse S100A7/psoriasin protein is a conservative change and the residue (E) remains negatively charged. Amino acid color-coding: non-polar (yellow), neutral polar (green), negatively charged (red). Hs = homo sapiens, Mm = Mus musculus. Adapted from .