Table 1 Comparison of tumor kinetics for four different MMR genotypes. The '+' and '-' symbols show the direction of change for each comparison. In each comparison, the genotype with the higher mutation rate had a lower acceleration and median age of onset.
From: Kinetics of cancer: a method to test hypotheses of genetic causation
Comparison | Type | Acceleration | Age | Mutation |
|---|---|---|---|---|
Mlh3 v Mlh3Pms2 | GI tumor | + | + | - |
Mlh3 v Mlh1 | GI tumor | + | + | - |
Mlh3 v Mlh3Pms2 | Lymphoma | + | + | - |
Mlh3 v Mlh1 | Lymphoma | + | + | - |
Pms2 v Mlh3Pms2 | Lymphoma | + | + | - |
Pms2 v Mlh1 | Lymphoma | + | + | - |
Mlh3 v Pms2 | Lymphoma | + | + | - |