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Table 1 Comparison of tumor kinetics for four different MMR genotypes. The '+' and '-' symbols show the direction of change for each comparison. In each comparison, the genotype with the higher mutation rate had a lower acceleration and median age of onset.

From: Kinetics of cancer: a method to test hypotheses of genetic causation

Comparison Type Acceleration Age Mutation
Mlh3 v Mlh3Pms2 GI tumor + + -
Mlh3 v Mlh1 GI tumor + + -
Mlh3 v Mlh3Pms2 Lymphoma + + -
Mlh3 v Mlh1 Lymphoma + + -
Pms2 v Mlh3Pms2 Lymphoma + + -
Pms2 v Mlh1 Lymphoma + + -
Mlh3 v Pms2 Lymphoma + + -