Expression of minichromosome maintenance protein 2 as a marker for proliferation and prognosis in diffuse large B-cell lymphoma: a tissue microarray and clinico-pathological analysis

Table 4 Clinico-pathologic and immunohistochemical parameters in relation to Mcm2 immunoreactivity

		Mcm2 immunoreactivity
Variable	Categorisation	n analysable	negative (<40%)	positive (≥40%)	p^a
*Clinico-pathologic data:*
Age at diagnosis
	<65 years	47	27	20	1.000
	≥65 years	63	37	26
Gender
	male	72	39	33	0.593
	female	57	34	23
Ann Arbor Stage
	1	15	10	5	0.342
	2	34	15	19
	3	23	14	9
	4	35	22	13
International prognostic index
	0	2	2	0	0.122
	1	48	27	21
	2	21	14	7
	3	20	13	7
	4	14	4	10
Bone marrow involvement
	no	72	39	33	0.414
	yes	35	22	13
Extranodal involvement
	no	40	27	13	0.103
	yes	62	31	31
Bulky disease
	no	62	44	20	0.003
	yes	35	13	22
Serum levels of LDH at diagnosis
	<300 U/l	42	23	19	0.505
	≥300 U/l	41	26	15

ISSN: 1471-2407