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Table 3 Effects of in vitro transcribed ENO1 mRNA constructs on cell growth after transfection into neuroblastoma (SK-N-AS), 293 and K562 cell lines.

From: Introduction of in vitro transcribed ENO1 mRNA into neuroblastoma cells induces cell death

cell line SK-N-AS 293 K562
mRNA day % decrease in
number of
cells +/-SD
no of exp p-value test % decrease in
number of
cells +/-SD
no of exp p-value test % decrease in
number of
cells +/-SD
no of exp p-value test
1.5 μg EGFP   - 4 × 8   - 3 × 8   - 2 × 4  
1.5 μg ENO1 1 58 +/- 12 4 × 8 < 10 -5 52 +/- 11 3 × 8 < 10 -3 -11 +/- 19 2 × 4 > 0.05
  2 81 +/- 11   < 10 -9 85 +/- 8   < 10 -5 13 +/- 34   > 0.05
  3 79 +/- 12   < 10 -9 89 +/- 16   < 10 -5 9 +/- 11   > 0.05
  4 76 +/- 17   < 10 -9 87 +/- 20   < 10 -5 10 +/- 9   0.03
0.3 μg ENO1 1 39 +/- 25 3 × 8 0.02 38 +/- 27 2 × 8 < 10 -4 -14 +/- 14 1 × 4 0.04
  2 63 +/- 15   < 10 -5 64 +/- 36   < 10 -4 6 +/- 11   > 0.05
  3 60 +/- 11   < 10 -5 60 +/- 54   < 10 -4 4 +/- 10   > 0.05
  4 64 +/- 13   < 10 -3 59 +/- 52   < 10 -5 -3 +/- 9   > 0.05
1.5 μg ENO1-mut 1 65 +/- 26 2 × 8 0.007 44 +/- 9 1 × 8 < 10 -3 -6 +/- 14 2 × 4 > 0.05
  2 84 +/- 8   < 10 -3 77 +/- 4   < 10 -6 20 +/- 8   0.004
  3 84 +/- 8   < 10 -4 73 +/- 6   < 10 -4 16 +/- 13   0.03
  4 84 +/- 7   < 10 -3 63 +/- 6   < 10 -6 5 +/- 11   > 0.05
0.3 μg ENO1-mut 1 66 +/- 8 1 × 8 < 10 -3 20 +/- 13 1 × 8 0.02 -18 +/- 13 1 × 4 0.01
  2 82 +/- 4   < 10 -6 50 +/- 7   < 10 -4 8 +/- 12   > 0.05
  3 70 +/- 7   < 10 -4 28 +/- 15   0.007 9 +/- 13   > 0.05
  4 72 +/- 6   < 10 -4 29 +/- 6   < 10 -4 -1 +/- 11   > 0.05
1.5 μg MBP-1 1 45 +/- 21 4 × 8 < 10 -3 41 +/- 8 3 × 8 0.005 -9 +/- 16 2 × 4 > 0.05
  2 67 +/- 13   < 10 -7 75 +/- 10   < 10 -4 10 +/- 12   > 0.05
  3 68 +/- 15   < 10 -6 82 +/- 25   < 10 -4 1 +/- 8   > 0.05
  4 64 +/- 20   < 10 -7 76 +/- 31   < 10 -4 5 +/- 9   > 0.05
0.3 μg MBP-1 1 25 +/- 18 3 × 8 > 0.05 50 +/- 38 2 × 8 0.02 -14 +/- 14 1 × 4 0.04
  2 47 +/- 18   0.001 56 +/- 18   < 10 -5 4 +/- 18   > 0.05
  3 38 +/- 7   0.001 44 +/- 46   < 10 -3 -11 +/- 17   > 0.05
  4 37 +/- 19   0.006 42 +/- 34   < 10 -4 -2 +/- 8   > 0.05