Skip to main content

Table 4 Comparisons between patients with an APC and/or K-ras mutation and absent hMLH1 expression.

From: Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study

  APC b and/or K-ras c mutation Absence of hMLH1 P-value
Number of patientsa 360   47   
Age at diagnosis (yr, mean (SD)) 67.8 (4.2) 69.3 (4.3) 0.03
Sex (% male) 58   40   0.02
Family history of colorectal cancer (% yes) 8   11   0.60
Tumour sub-localisation      <0.001
   Proximal colon 96 (70%) 41 (30%)  
   Distal colon 107 (97%) 3 (3%)  
   Rectosigmoid 51 (100%) 0 (0%)  
   Rectum 100 (97%) 3 (3%)  
Dukes' stage      0.08
   A 86 (90%) 10 (10%)  
   B 117 (84%) 23 (16%)  
   C 89 (91%) 9 (9%)  
   D 47 (94%) 3 (6%)  
Differentiation      <0.001
   Good 37 (92%) 3 (8%)  
   Moderate 232 (92%) 20 (8%)  
   Poor 43 (78%) 12 (22%)  
   Undifferentiated 1 (33%) 2 (67%)  
  1. a Patients with both absent hMLH1 expression and an APC or K-ras mutation were excluded from the analysis.
  2. b APC mutations: only mutations resulting in a stop codon.
  3. c K-ras mutations: only activating mutations in codon 12 or 13.